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Open AccessArticle

A New Approach for Glyco-Functionalization of Collagen-Based Biomaterials

1
Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy
2
School of Medicine and Surgery, University of Milano-Bicocca, 20854 Vedano al Lambro, Italy
3
Department of Material Science, University of Milano-Bicocca, 20126 Milan, Italy
4
UNITECH COSPECT: Comprehensive Substances characterization via advanced sPECTtrometry, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1747; https://doi.org/10.3390/ijms20071747
Received: 17 March 2019 / Revised: 1 April 2019 / Accepted: 3 April 2019 / Published: 9 April 2019
(This article belongs to the Special Issue Cell-Biomaterial Interaction 2019)
The cell microenvironment plays a pivotal role in mediating cell adhesion, survival, and proliferation in physiological and pathological states. The relevance of extracellular matrix (ECM) proteins in cell fate control is an important issue to take into consideration for both tissue engineering and cell biology studies. The glycosylation of ECM proteins remains, however, largely unexplored. In order to investigate the physio-pathological effects of differential ECM glycosylation, the design of affordable chemoselective methods for ECM components glycosylation is desirable. We will describe a new chemoselective glycosylation approach exploitable in aqueous media and on non-protected substrates, allowing rapid access to glyco-functionalized biomaterials. View Full-Text
Keywords: biofunctionalization; glyco-microenvironment; cell fate; ECM mimetics; tissue engineering biofunctionalization; glyco-microenvironment; cell fate; ECM mimetics; tissue engineering
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MDPI and ACS Style

Figuereido, I.; Paiotta, A.; Dal Magro, R.; Tinelli, F.; Corti, R.; Re, F.; Cassina, V.; Caneva, E.; Nicotra, F.; Russo, L. A New Approach for Glyco-Functionalization of Collagen-Based Biomaterials. Int. J. Mol. Sci. 2019, 20, 1747.

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