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Int. J. Mol. Sci. 2019, 20(6), 1482;

Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis

Department of Medicine and Surgery, University of Insubria, via H Dunant 5, 21100 Varese, Italy
Department of Internal Medicine and Therapeutics, Section of Pharmacology, University of Pavia, via Ferrata 9, 27100 Pavia, Italy
Department of Biotechnology and Life Sciences, University of Insubria, via H Dunant 5, 21100 Varese, Italy
Author to whom correspondence should be addressed.
Received: 21 January 2019 / Revised: 4 March 2019 / Accepted: 21 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Glutamate Receptors in Health and Disease)
PDF [1616 KB, uploaded 25 March 2019]


A complex bidirectional communication system exists between the gastrointestinal tract and the brain. Initially termed the “gut-brain axis” it is now renamed the “microbiota-gut-brain axis” considering the pivotal role of gut microbiota in maintaining local and systemic homeostasis. Different cellular and molecular pathways act along this axis and strong attention is paid to neuroactive molecules (neurotransmitters, i.e., noradrenaline, dopamine, serotonin, gamma aminobutyric acid and glutamate and metabolites, i.e., tryptophan metabolites), sustaining a possible interkingdom communication system between eukaryota and prokaryota. This review provides a description of the most up-to-date evidence on glutamate as a neurotransmitter/neuromodulator in this bidirectional communication axis. Modulation of glutamatergic receptor activity along the microbiota-gut-brain axis may influence gut (i.e., taste, visceral sensitivity and motility) and brain functions (stress response, mood and behavior) and alterations of glutamatergic transmission may participate to the pathogenesis of local and brain disorders. In this latter context, we will focus on two major gut disorders, such as irritable bowel syndrome and inflammatory bowel disease, both characterized by psychiatric co-morbidity. Research in this area opens the possibility to target glutamatergic neurotransmission, either pharmacologically or by the use of probiotics producing neuroactive molecules, as a therapeutic approach for the treatment of gastrointestinal and related psychiatric disorders. View Full-Text
Keywords: microbiota-gut-brain axis; glutamate; glutamate receptors; dysbiosis; irritable bowel syndrome (IBS); inflammatory bowel disease (IBD) microbiota-gut-brain axis; glutamate; glutamate receptors; dysbiosis; irritable bowel syndrome (IBS); inflammatory bowel disease (IBD)

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Baj, A.; Moro, E.; Bistoletti, M.; Orlandi, V.; Crema, F.; Giaroni, C. Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis. Int. J. Mol. Sci. 2019, 20, 1482.

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