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Int. J. Mol. Sci. 2019, 20(5), 1135; https://doi.org/10.3390/ijms20051135

Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators

1
Center for Cooperative Research in Biosciences (CIC bioGUNE), Bizkaia Science and Technology Park Bld 800, 48160 Derio, Bizkaia, Spain
2
Department of Pediatric Gastroenterology, Nephrology and Metabolic Disorders, Charité Universitäts Medizin, Berlin, 13353 Berlin, Germany
3
Liver Disease Lab, CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 48160 Derio, Bizkaia, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 21 January 2019 / Revised: 28 February 2019 / Accepted: 1 March 2019 / Published: 6 March 2019
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Abstract

The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The human family includes four members, whose impaired activity causes diseases such as Jalili Syndrome or Familial Hypomagnesemia, but is also linked to neuropathologic disorders, altered blood pressure, and infertility. Recent findings demonstrated that CNNMs are associated with the highly oncogenic phosphatases of the regenerating liver to promote tumor growth and metastasis, which has attracted renewed focus on their potential exploitation as targets for cancer treatment. However, the exact function of CNNMs remains unclear and is subject to debate, proposed as either direct transporters, sensors, or homeostatic factors. This review gathers the current structural knowledge on the CNNM family, highlighting similarities and differences with the closely related structural partners such as the bacterial Mg2+/Co2+ efflux protein CorC and the Mg2+ channel MgtE. View Full-Text
Keywords: CNNM; ACDP; magnesium homeostasis; magnesium transport; CBS domain; cNMP domain; CNBH domain; Jalili syndrome; hypomagnesemia; cancer CNNM; ACDP; magnesium homeostasis; magnesium transport; CBS domain; cNMP domain; CNBH domain; Jalili syndrome; hypomagnesemia; cancer
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Giménez-Mascarell, P.; González-Recio, I.; Fernández-Rodríguez, C.; Oyenarte, I.; Müller, D.; Martínez-Chantar, M.L.; Martínez-Cruz, L.A. Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators. Int. J. Mol. Sci. 2019, 20, 1135.

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