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Int. J. Mol. Sci. 2019, 20(4), 816; https://doi.org/10.3390/ijms20040816

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer

1
,
1,2
,
1,2,3,4,5,6
and
1,*
1
School of Medicine, Western Sydney University, Penrith, NSW 2751, Australia
2
Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia
3
Department of Anatomical Pathology, Liverpool Hospital, Liverpool, NSW 2170, Australia
4
Discipline of Pathology, School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia
5
Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Liverpool, NSW 2170, Australia
6
Faculty of Medicine and Health, Central Clinical School, University of Sydney, Camperdown, NSW 2050, Australia
*
Author to whom correspondence should be addressed.
Received: 13 January 2019 / Revised: 12 February 2019 / Accepted: 12 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue Basic and Translational Research in Colorectal Cancer)
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Abstract

The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The identification of MRN complex mutations in mismatch repair (MMR)-defective cancers has sparked interest in its role in colorectal cancer (CRC). To date, there is evidence indicating a relationship of MRN expression with reduced progression-free survival, although the significance of the MRN complex in the clinical setting remains controversial. In this review, we present an overview of the function of the MRN complex, its role in cancer progression, and current evidence in colorectal cancer. The evidence indicates that the MRN complex has potential utilisation as a biomarker and as a putative treatment target to improve outcomes of colorectal cancer. View Full-Text
Keywords: DNA damage response; MRE11-RAD50-NBS1 complex; colorectal cancer; biomarkers; prognosis; radiosensitivity DNA damage response; MRE11-RAD50-NBS1 complex; colorectal cancer; biomarkers; prognosis; radiosensitivity
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Situ, Y.; Chung, L.; Lee, C.S.; Ho, V. MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer. Int. J. Mol. Sci. 2019, 20, 816.

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