Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
Abstract
:1. Introduction
2. General Properties of Several Main Human hnRNPs Involved in Telomere Functions
2.1. HnRNP with Two RRM Domains
2.1.1. HnRNP-A1 and Other Members of the hnRNP-A/B Family
2.1.2. HnRNP-D1 and hnRNP-DL
2.2. HnRNPs with One RRM Domain
2.3. HnRNPs with qRRM Domains
2.4. HnRNPs with KH (the K Homology (KH) domain) Domains
2.5. HnRNPs with RGG/RG Domain
3. Human Telomeres and Their Relationship with Some hnRNPs in HMCs
3.1. CST Complex and Some Other Participants of Telomere–Protein Relationships
3.2. Members of hnRNP-A/B Family and Telomeres of HMCs
3.2.1. Isoforms of hnRNP-A1 and hnRNP-A2
3.2.2. HnRNP-A18
3.3. Several Other hnRNPs with RRM Domains and Telomeres of HMCs
3.4. HnRNPs without RRM Domains and Telomeres of HMCs
4. Discussion
5. Conclusions
Funding
Acknowledgements
Conflicts of Interest
References
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Members of hnRNP-A/B Family | RRM-1 | RRM-2 | ||
---|---|---|---|---|
RNP-1 | RNP-2 | RNP-1 | RNP-2 | |
hnRNP-A1 | 55 62 RGFGFVTY | 16 21 LFIGGL | 116 153 RGFAFVTF | 107 112 IFVGGI |
hnRNP-B1 | 62 69 RGFGFVTF | 23 28 LFIGGL | 153 160 RGFGFVTF | 114 119 LFVGGI |
hnRNP-A3 | 76 83 RGFGFVTY | 37 42 LFIGGL | 167 174 RGFAFVTF | 128 133 IFVGGI |
hnRNP-A0 | 48 55 RCFGFVTY | 9 14 LFIGGL | 139 146 RGFAFVTF | 100 105 LFVGGL |
hnRNP-A1-like 2 | 55 62 RGFGFVTY | 16 21 LFIGGL | 156 163 RGFAFVTF | 107 112 IFVGGI |
hnRNP-AB | 110 117 RGFGFILF | 71 76 MFVGGL | 195 202 RGFVFITF | 155 160 IFVGGL |
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Shishkin, S.S.; Kovalev, L.I.; Pashintseva, N.V.; Kovaleva, M.A.; Lisitskaya, K. Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells. Int. J. Mol. Sci. 2019, 20, 745. https://doi.org/10.3390/ijms20030745
Shishkin SS, Kovalev LI, Pashintseva NV, Kovaleva MA, Lisitskaya K. Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells. International Journal of Molecular Sciences. 2019; 20(3):745. https://doi.org/10.3390/ijms20030745
Chicago/Turabian StyleShishkin, Sergey S., Leonid I. Kovalev, Natalya V. Pashintseva, Marina A. Kovaleva, and Ksenia Lisitskaya. 2019. "Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells" International Journal of Molecular Sciences 20, no. 3: 745. https://doi.org/10.3390/ijms20030745