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Current Coverage of the mTOR Pathway by Next-Generation Sequencing Oncology Panels

by 1,2,†, 2,† and 3,4,5,6,*
1
Clinical Institute of Pathology, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, 3100 St. Pölten, Austria
2
Department Life Sciences, IMC University of Applied Sciences Krems, 3500 Krems, Austria
3
Department of Pathology, Medical Faculty, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany
4
Department of Pathology, Neuropathology, and Molecular Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria
5
Department of Neuropathology, Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, 8036 Graz, Austria
6
German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(3), 690; https://doi.org/10.3390/ijms20030690
Received: 16 January 2019 / Revised: 28 January 2019 / Accepted: 29 January 2019 / Published: 5 February 2019
(This article belongs to the Special Issue mTOR in Human Diseases)
The mTOR pathway is in the process of establishing itself as a key access-point of novel oncological drugs and targeted therapies. This is also reflected by the growing number of mTOR pathway genes included in commercially available next-generation sequencing (NGS) oncology panels. This review summarizes the portfolio of medium sized diagnostic, as well as research destined NGS panels and their coverage of the mTOR pathway, including 16 DNA-based panels and the current gene list of Foundation One as a major reference entity. In addition, we give an overview of interesting, mTOR-associated somatic mutations that are not yet incorporated. Especially eukaryotic translation initiation factors (eIFs), a group of mTOR downstream proteins, are on the rise as far as diagnostics and drug targeting in precision medicine are concerned. This review aims to raise awareness for the true coverage of NGS panels, which should be valuable in selecting the ideal platform for diagnostics and research. View Full-Text
Keywords: mTOR; NGS; illumina; IonTorrent; eIFs mTOR; NGS; illumina; IonTorrent; eIFs
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MDPI and ACS Style

Seeboeck, R.; Sarne, V.; Haybaeck, J. Current Coverage of the mTOR Pathway by Next-Generation Sequencing Oncology Panels. Int. J. Mol. Sci. 2019, 20, 690. https://doi.org/10.3390/ijms20030690

AMA Style

Seeboeck R, Sarne V, Haybaeck J. Current Coverage of the mTOR Pathway by Next-Generation Sequencing Oncology Panels. International Journal of Molecular Sciences. 2019; 20(3):690. https://doi.org/10.3390/ijms20030690

Chicago/Turabian Style

Seeboeck, Rita; Sarne, Victoria; Haybaeck, Johannes. 2019. "Current Coverage of the mTOR Pathway by Next-Generation Sequencing Oncology Panels" Int. J. Mol. Sci. 20, no. 3: 690. https://doi.org/10.3390/ijms20030690

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