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Open AccessArticle

Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib

1
Leibniz-Institut für Polymerforschung Dresden e.V., Department Polyelectrolytes and Dispersions, Hohe Straße 6, 01069 Dresden, Germany
2
Technische Universität Dresden, Department of Chemistry and Food Chemistry, 01062 Dresden, Germany
3
Universität Paderborn, Department of Chemistry, Warburger Str. 100, 33106 Paderborn, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(23), 6081; https://doi.org/10.3390/ijms20236081
Received: 29 October 2019 / Revised: 27 November 2019 / Accepted: 29 November 2019 / Published: 2 December 2019
(This article belongs to the Special Issue Wet Adhesion: New Chemistries, Models and Translation to Materials)
To overcome the high relapse rate of multiple myeloma (MM), a drug delivery coating for functionalization of bone substitution materials (BSM) is reported based on adhesive, catechol-containing and stimuli-responsive polyelectrolyte complexes (PECs). This system is designed to deliver the MM drug bortezomib (BZM) directly to the anatomical site of action. To establish a gradual BZM release, the naturally occurring caffeic acid (CA) is coupled oxidatively to form poly(caffeic acid) (PCA), which is used as a polyanion for complexation. The catechol functionalities within the PCA are particularly suitable to form esters with the boronic acid group of the BZM, which are then cleaved in the body fluid to administer the drug. To achieve a more thorough control of the release, the thermoresponsive poly(N-isoproplyacrylamide-co-dimethylaminoethylmethacrylate) (P(NIPAM-co-DMAEMA)) was used as a polycation. Using turbidity measurements, it was proven that the lower critical solution temperature (LCST) character of this polymer was transferred to the PECs. Further special temperature dependent attenuated total reflection infrared spectroscopy (ATR-FTIR) showed that coatings formed by PEC immobilization exhibit a similar thermoresponsive performance. By loading the coatings with BZM and studying the release in a model system, via UV/Vis it was observed, that both aims, the retardation and the stimuli control of the release, were achieved. View Full-Text
Keywords: catechol chemistry; poly(caffeic acid); polyelectrolyte complex coatings; thermoresponsive coatings; controlled release; bortezomib; multiple myeloma catechol chemistry; poly(caffeic acid); polyelectrolyte complex coatings; thermoresponsive coatings; controlled release; bortezomib; multiple myeloma
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MDPI and ACS Style

Reis, B.; Vehlow, D.; Rust, T.; Kuckling, D.; Müller, M. Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib. Int. J. Mol. Sci. 2019, 20, 6081.

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