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Melanoma and Vitiligo: In Good Company

Experimental Immunology Laboratory, IDI-IRCCS, 00167 Rome, Italy
Epidemiology Unit, IDI-IRCCS, 00167 Rome, Italy
1st Dermatology Division, IDI-IRCCS, 00167 Rome, Italy
Molecular Oncology Laboratory, IDI-IRCCS, 00167 Rome, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(22), 5731;
Received: 14 October 2019 / Revised: 10 November 2019 / Accepted: 13 November 2019 / Published: 15 November 2019
(This article belongs to the Special Issue Skin Cancer: From Pathophysiology to Novel Therapeutic Approaches)
Cutaneous melanoma represents the most aggressive form of skin cancer, whereas vitiligo is an autoimmune disorder that leads to progressive destruction of skin melanocytes. However, vitiligo has been associated with cutaneous melanoma since the 1970s. Most of the antigens recognized by the immune system are expressed by both melanoma cells and normal melanocytes, explaining why the autoimmune response against melanocytes that led to vitiligo could be also present in melanoma patients. Leukoderma has been also observed as a side effect of melanoma immunotherapy and has always been associated with a favorable prognosis. In this review, we discuss several characteristics of the immune system responses shared by melanoma and vitiligo patients, as well as the significance of occurrence of leukoderma during immunotherapy, with special attention to check-point inhibitors. View Full-Text
Keywords: melanoma; autoimmunity; prognostic markers melanoma; autoimmunity; prognostic markers
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MDPI and ACS Style

Failla, C.M.; Carbone, M.L.; Fortes, C.; Pagnanelli, G.; D’Atri, S. Melanoma and Vitiligo: In Good Company. Int. J. Mol. Sci. 2019, 20, 5731.

AMA Style

Failla CM, Carbone ML, Fortes C, Pagnanelli G, D’Atri S. Melanoma and Vitiligo: In Good Company. International Journal of Molecular Sciences. 2019; 20(22):5731.

Chicago/Turabian Style

Failla, Cristina M., Maria L. Carbone, Cristina Fortes, Gianluca Pagnanelli, and Stefania D’Atri. 2019. "Melanoma and Vitiligo: In Good Company" International Journal of Molecular Sciences 20, no. 22: 5731.

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