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Open AccessArticle

The Alteration of CTNNBIP1 in Lung Cancer

Department of Surgery, Division of Thoracic Surgery, Chia-Yi Christian Hospital, Chiayi 60002, Taiwan
Department of Physical Therapy, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan
Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 97004, Taiwan
GLORIA Operation Center, National Tsing Hua University, Hsinchu 30013, Taiwan
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(22), 5684;
Received: 28 September 2019 / Revised: 7 November 2019 / Accepted: 12 November 2019 / Published: 13 November 2019
(This article belongs to the Section Biochemistry)
β-catenin is a major component of the Wnt/β-catenin signaling pathway, and is known to play a role in lung tumorigenesis. β-catenin-interacting protein 1 (CTNNBIP1) is a known repressor of β-catenin transactivation. However, little is known about the role of CTNNBIP1 in lung cancer. The aim of this study was to carry out a molecular analysis of CTNNBIP1 and its effect on β-catenin signaling, using samples from lung cancer patients and various lung cancer cell lines. Our results indicate a significant inverse correlation between the CTNNBIP1 mRNA expression levels and the CTNNBIP1 promoter hypermethylation, which suggests that the promoter hypermethylation is responsible for the low levels of CTNNBIP1 present in many lung cancer patient samples. The ectopic expression of CTNNBIP1 is able to reduce the β-catenin transactivation; this then brings about a decrease in the expression of β-catenin-targeted genes, such as matrix metalloproteinase 7 (MMP7). Conversely, CTNNBIP1 knockdown is able to increase β-catenin transactivation and the expression of MMP7. In agreement with these findings, a low level of CTNNBIP1 was found to be correlated with a high level of MMP7 when a publicly available microarray dataset for lung cancer was analyzed. Also, in agreement with the above, the ectopic expression of CTNNBIP1 inhibits the migration of lung cancer cells, whereas the CTNNBIP1 knockdown increases cancer cell migration. Our findings suggest that CTNNBIP1 is a suppressor of cancer migration, thus making it a potential prognostic predictor for lung cancer. View Full-Text
Keywords: CTNNBIP1; β-catenin; lung cancer CTNNBIP1; β-catenin; lung cancer
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MDPI and ACS Style

Chang, J.-M.; Tsai, A.C.-D.; Huang, W.-R.; Tseng, R.-C. The Alteration of CTNNBIP1 in Lung Cancer. Int. J. Mol. Sci. 2019, 20, 5684.

AMA Style

Chang J-M, Tsai AC-D, Huang W-R, Tseng R-C. The Alteration of CTNNBIP1 in Lung Cancer. International Journal of Molecular Sciences. 2019; 20(22):5684.

Chicago/Turabian Style

Chang, Jia-Ming; Tsai, Alexander C.-D.; Huang, Way-Ren; Tseng, Ruo-Chia. 2019. "The Alteration of CTNNBIP1 in Lung Cancer" Int. J. Mol. Sci. 20, no. 22: 5684.

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