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Review

Glucagon Regulation of Energy Expenditure

1
Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Centre Munich, Ingolstädter Landstraße 1, 85764 Oberschleißheim, Germany
2
Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark
3
Division of Metabolic Diseases, Technische Universität München, 85740 Munich, Germany
4
Department of Medicine-Endocrinology and Comprehensive Diabetes Center, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35899, USA
5
Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany
6
German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany
7
Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany
8
Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, 72076 Tübingen, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(21), 5407; https://doi.org/10.3390/ijms20215407
Received: 30 September 2019 / Revised: 23 October 2019 / Accepted: 24 October 2019 / Published: 30 October 2019
(This article belongs to the Special Issue The Biology and Pharmacology of Glucagon)
Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects. View Full-Text
Keywords: glucagon; obesity; energy expenditure; FGF21; brown adipose tissue; pharmacology glucagon; obesity; energy expenditure; FGF21; brown adipose tissue; pharmacology
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MDPI and ACS Style

Kleinert, M.; Sachs, S.; Habegger, K.M.; Hofmann, S.M.; Müller, T.D. Glucagon Regulation of Energy Expenditure. Int. J. Mol. Sci. 2019, 20, 5407. https://doi.org/10.3390/ijms20215407

AMA Style

Kleinert M, Sachs S, Habegger KM, Hofmann SM, Müller TD. Glucagon Regulation of Energy Expenditure. International Journal of Molecular Sciences. 2019; 20(21):5407. https://doi.org/10.3390/ijms20215407

Chicago/Turabian Style

Kleinert, Maximilian; Sachs, Stephan; Habegger, Kirk M.; Hofmann, Susanna M.; Müller, Timo D. 2019. "Glucagon Regulation of Energy Expenditure" Int. J. Mol. Sci. 20, no. 21: 5407. https://doi.org/10.3390/ijms20215407

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