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Review

Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

1
Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
2
CEMIN, Center of Excellence on Nanostructured Innovative Materials, Via del Giochetto, 06126 Perugia, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(21), 5337; https://doi.org/10.3390/ijms20215337
Received: 8 October 2019 / Revised: 23 October 2019 / Accepted: 25 October 2019 / Published: 26 October 2019
(This article belongs to the Special Issue Mechanobiology in Cells and Tissues)
The cross-talk between stem cells and their microenvironment has been shown to have a direct impact on stem cells’ decisions about proliferation, growth, migration, and differentiation. It is well known that stem cells, tissues, organs, and whole organisms change their internal architecture and composition in response to external physical stimuli, thanks to cells’ ability to sense mechanical signals and elicit selected biological functions. Likewise, stem cells play an active role in governing the composition and the architecture of their microenvironment. Is now being documented that, thanks to this dynamic relationship, stemness identity and stem cell functions are maintained. In this work, we review the current knowledge in mechanobiology on stem cells. We start with the description of theoretical basis of mechanobiology, continue with the effects of mechanical cues on stem cells, development, pathology, and regenerative medicine, and emphasize the contribution in the field of the development of ex-vivo mechanobiology modelling and computational tools, which allow for evaluating the role of forces on stem cell biology. View Full-Text
Keywords: stem cells; mechanotransduction; mechanosensing; regenerative medicine; ex-vivo stem cell models; computational tools; stem cell-biomaterial interaction stem cells; mechanotransduction; mechanosensing; regenerative medicine; ex-vivo stem cell models; computational tools; stem cell-biomaterial interaction
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MDPI and ACS Style

Argentati, C.; Morena, F.; Tortorella, I.; Bazzucchi, M.; Porcellati, S.; Emiliani, C.; Martino, S. Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions. Int. J. Mol. Sci. 2019, 20, 5337. https://doi.org/10.3390/ijms20215337

AMA Style

Argentati C, Morena F, Tortorella I, Bazzucchi M, Porcellati S, Emiliani C, Martino S. Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions. International Journal of Molecular Sciences. 2019; 20(21):5337. https://doi.org/10.3390/ijms20215337

Chicago/Turabian Style

Argentati, Chiara, Francesco Morena, Ilaria Tortorella, Martina Bazzucchi, Serena Porcellati, Carla Emiliani, and Sabata Martino. 2019. "Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions" International Journal of Molecular Sciences 20, no. 21: 5337. https://doi.org/10.3390/ijms20215337

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