Next Article in Journal
Comparative Genome-wide Analysis and Expression Profiling of Histone Acetyltransferase (HAT) Gene Family in Response to Hormonal Applications, Metal and Abiotic Stresses in Cotton
Previous Article in Journal
Sulfolobus acidocaldarius Microvesicles Exhibit Unusually Tight Packing Properties as Revealed by Optical Spectroscopy
Review

Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology

1
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
2
Center for Research and Education in Nanobioengineering, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
3
Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
4
James A Haley VA Hospital, Tampa, FL 33612, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(21), 5310; https://doi.org/10.3390/ijms20215310
Received: 8 October 2019 / Revised: 18 October 2019 / Accepted: 20 October 2019 / Published: 25 October 2019
(This article belongs to the Section Molecular Oncology)
Ashwagandha (Withania Somnifera, WS), belonging to the family Solanaceae, is an Ayurvedic herb known worldwide for its numerous beneficial health activities since ancient times. This medicinal plant provides benefits against many human illnesses such as epilepsy, depression, arthritis, diabetes, and palliative effects such as analgesic, rejuvenating, regenerating, and growth-promoting effects. Several clinical trials of the different parts of the herb have demonstrated safety in patients suffering from these diseases. In the last two decades, an active component of Withaferin A (WFA) has shown tremendous cytotoxic activity suggesting its potential as an anti-carcinogenic agent in treatment of several cancers. In spite of enormous progress, a thorough elaboration of the proposed mechanism and mode of action is absent. Herein, we provide a comprehensive review of the properties of WS extracts (WSE) containing complex mixtures of diverse components including WFA, which have shown inhibitory properties against many cancers, (breast, colon, prostate, colon, ovarian, lung, brain), along with their mechanism of actions and pathways involved. View Full-Text
Keywords: cancer; mechanism of action; Withania Somnifera; Withaferin A cancer; mechanism of action; Withania Somnifera; Withaferin A
Show Figures

Graphical abstract

MDPI and ACS Style

Dutta, R.; Khalil, R.; Green, R.; Mohapatra, S.S.; Mohapatra, S. Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology. Int. J. Mol. Sci. 2019, 20, 5310. https://doi.org/10.3390/ijms20215310

AMA Style

Dutta R, Khalil R, Green R, Mohapatra SS, Mohapatra S. Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology. International Journal of Molecular Sciences. 2019; 20(21):5310. https://doi.org/10.3390/ijms20215310

Chicago/Turabian Style

Dutta, Rinku, Roukiah Khalil, Ryan Green, Shyam S. Mohapatra, and Subhra Mohapatra. 2019. "Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology" International Journal of Molecular Sciences 20, no. 21: 5310. https://doi.org/10.3390/ijms20215310

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop