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Open AccessReview

The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity

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Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania
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Internal Medicine Clinic, “Sf. Spiridon” County Clinical Emergency Hospital Iasi, 700115 Iasi, Romania
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Department of Cardiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania
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Cardiology Clinic, “Prof. Dr. George I.M. Georgescu” Institute of Cardiovascular Diseases, 700503 Iasi, Romania
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Department of Ophthalmology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
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2nd Ophthalmology Clinic, “Prof. Dr. Nicolae Oblu” Emergency Clinical Hospital, 700115 Iași, Romania
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Department of Pathophysiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
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Department of Obstetrics and Gynecology, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania
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Unit of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
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Clinical Center of Diabetes, Nutrition and Metabolic Diseases, “Sf. Spiridon” County Clinical Emergency Hospital, 700111 Iasi, Romania
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Department of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5238; https://doi.org/10.3390/ijms20205238
Received: 19 September 2019 / Revised: 9 October 2019 / Accepted: 17 October 2019 / Published: 22 October 2019
(This article belongs to the Special Issue Nephrotoxicity 2019)
Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI. View Full-Text
Keywords: kidney injury molecule-1; acute kidney injury; cisplatin nephrotoxicity kidney injury molecule-1; acute kidney injury; cisplatin nephrotoxicity
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MDPI and ACS Style

Tanase, D.M.; Gosav, E.M.; Radu, S.; Costea, C.F.; Ciocoiu, M.; Carauleanu, A.; Lacatusu, C.M.; Maranduca, M.A.; Floria, M.; Rezus, C. The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity. Int. J. Mol. Sci. 2019, 20, 5238.

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