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Open AccessReview

Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms

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Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran
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Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran
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Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad 9691793718, Iran
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Kidney Research Center, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran
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Women′s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz 5138663134, Iran
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Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran
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Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol 4617647745, Iran
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Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran
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Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran
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Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran
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Research Laboratories, Bambino Gesù Children′s Hospital-IRCCS, Rome 00146, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5088; https://doi.org/10.3390/ijms20205088
Received: 19 July 2019 / Revised: 24 September 2019 / Accepted: 10 October 2019 / Published: 14 October 2019
(This article belongs to the Section Molecular Oncology)
Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsistent findings in the literature should be detected and resolved to facilitate the genetic screening of miRNA polymorphisms, even during childhood or adolescence, and their use as predictors of future malignancies. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and the risk of female neoplasms. Meta-analysis was performed by pooling odds-ratios (ORs) and generalized ORs while using a random-effects model for 15 miRNA polymorphisms. The results suggest that miR-146a rs2910164 is implicated in the susceptibility to GCa. Moreover, miR-196a2 rs11614913-T had a moderate protective effect against female neoplasms, especially GCa, in Asians but not in Caucasians. MiR-27a rs895819-G might pose a protective effect against BCa among Caucasians. MiR-499 rs3746444-C may slightly increase the risk of female neoplasms, especially BCa. MiR-124 rs531564-G may be associated with a lower risk of female neoplasms. The current evidences do not support the association of the remaining polymorphisms and the risk of female neoplasms. View Full-Text
Keywords: microRNA; polymorphism; breast neoplasm; female neoplasm; susceptibility; cancer microRNA; polymorphism; breast neoplasm; female neoplasm; susceptibility; cancer
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MDPI and ACS Style

Bastami, M.; Choupani, J.; Saadatian, Z.; Zununi Vahed, S.; Ouladsahebmadarek, E.; Mansoori, Y.; Daraei, A.; Samadi Kafil, H.; Yousefi, B.; Mahdipour, M.; Masotti, A.; Nariman-Saleh-Fam, Z. Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms. Int. J. Mol. Sci. 2019, 20, 5088. https://doi.org/10.3390/ijms20205088

AMA Style

Bastami M, Choupani J, Saadatian Z, Zununi Vahed S, Ouladsahebmadarek E, Mansoori Y, Daraei A, Samadi Kafil H, Yousefi B, Mahdipour M, Masotti A, Nariman-Saleh-Fam Z. Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms. International Journal of Molecular Sciences. 2019; 20(20):5088. https://doi.org/10.3390/ijms20205088

Chicago/Turabian Style

Bastami, Milad; Choupani, Jalal; Saadatian, Zahra; Zununi Vahed, Sepideh; Ouladsahebmadarek, Elaheh; Mansoori, Yasser; Daraei, Abdolreza; Samadi Kafil, Hossein; Yousefi, Bahman; Mahdipour, Mahdi; Masotti, Andrea; Nariman-Saleh-Fam, Ziba. 2019. "Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms" Int. J. Mol. Sci. 20, no. 20: 5088. https://doi.org/10.3390/ijms20205088

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