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Int. J. Mol. Sci. 2019, 20(2), 315; https://doi.org/10.3390/ijms20020315

Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

1
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea
2
Bio-Health Convergence Institute, Korea Testing Certification, Gunpo 15809, Korea
*
Author to whom correspondence should be addressed.
Received: 18 December 2018 / Revised: 8 January 2019 / Accepted: 12 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)
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Abstract

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO2@Ag NPs and then successfully released. Neither cysteinyl-β-CD and EDA-β-CD showed cytotoxicity, while DOX-loaded cysteinyl-β-CD and EDA-β-CD showed a significant decrease in cell viability in cancer cells. The SiO2@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types. View Full-Text
Keywords: cyclodextrin; doxorubicin (DOX); drug delivery cyclodextrin; doxorubicin (DOX); drug delivery
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Kang, E.J.; Baek, Y.M.; Hahm, E.; Lee, S.H.; Pham, X.-H.; Noh, M.S.; Kim, D.-E.; Jun, B.-H. Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier. Int. J. Mol. Sci. 2019, 20, 315.

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