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Open AccessArticle

Fluorescence Quenching-Based Mechanism for Determination of Hypochlorite by Coumarin-Derived Sensors

1
Department of Analytical Chemistry (C1), Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Cracow, Poland
2
Department of Biophysics, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
3
Centre of Applied Science for Health, Institute of Technology Tallaght, Dublin 24, Ireland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(2), 281; https://doi.org/10.3390/ijms20020281
Received: 12 December 2018 / Revised: 3 January 2019 / Accepted: 9 January 2019 / Published: 11 January 2019
(This article belongs to the Section Molecular Biophysics)
A fluorescence quenching-based mechanism for the determination of hypochlorite was proposed based on spectroscopic and chromatographic studies on the hypochlorite-sensing potency of three structurally similar and highly fluorescent coumarins. The mode of action was found to rely upon a chlorination of the coumarin-based probes resulting from their reaction with sodium hypochlorite. Importantly, the formation of chlorinated derivatives was accompanied by a linear decrease in the fluorescence intensities of the probes tested. The results obtained suggest the applicability of a coumarin-dependent hypochlorite recognition mechanism for the detection of, as well as for quantitative determination of, hypochlorite species in vitro. View Full-Text
Keywords: coumarin; hypochlorite sensing; fluorescence quenching coumarin; hypochlorite sensing; fluorescence quenching
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MDPI and ACS Style

Starzak, K.; Matwijczuk, A.; Creaven, B.; Matwijczuk, A.; Wybraniec, S.; Karcz, D. Fluorescence Quenching-Based Mechanism for Determination of Hypochlorite by Coumarin-Derived Sensors. Int. J. Mol. Sci. 2019, 20, 281. https://doi.org/10.3390/ijms20020281

AMA Style

Starzak K, Matwijczuk A, Creaven B, Matwijczuk A, Wybraniec S, Karcz D. Fluorescence Quenching-Based Mechanism for Determination of Hypochlorite by Coumarin-Derived Sensors. International Journal of Molecular Sciences. 2019; 20(2):281. https://doi.org/10.3390/ijms20020281

Chicago/Turabian Style

Starzak, Karolina; Matwijczuk, Arkadiusz; Creaven, Bernadette; Matwijczuk, Alicja; Wybraniec, Sławomir; Karcz, Dariusz. 2019. "Fluorescence Quenching-Based Mechanism for Determination of Hypochlorite by Coumarin-Derived Sensors" Int. J. Mol. Sci. 20, no. 2: 281. https://doi.org/10.3390/ijms20020281

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