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Protective Effects of Melatonin on the Skin: Future Perspectives

1
Biomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, Spain
2
Department of Physiology, University of Granada, 18016 Granada, Spain
3
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Investigación Biosanitaria CIBERFES, IBS. Granada, Granada Hospital Complex, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4948; https://doi.org/10.3390/ijms20194948
Received: 16 September 2019 / Revised: 30 September 2019 / Accepted: 7 October 2019 / Published: 8 October 2019
(This article belongs to the Section Biochemistry)
When exposed to hostile environments such as radiation, physical injuries, chemicals, pollution, and microorganisms, the skin requires protective chemical molecules and pathways. Melatonin, a highly conserved ancient molecule, plays a crucial role in the maintenance of skin. As human skin has functional melatonin receptors and also acts as a complete system that is capable of producing and regulating melatonin synthesis, melatonin is a promising candidate for its maintenance and protection. Below, we review the studies of new metabolic pathways involved in the protective functions of melatonin in dermal cells. We also discuss the advantages of the topical use of melatonin for therapeutic purposes and skin protection. In our view, endogenous intracutaneous melatonin production, together with topically-applied exogenous melatonin and its metabolites, represent two of the most potent defense systems against external damage to the skin. View Full-Text
Keywords: skin; melatonin; mitochondria; oxidative stress; aging skin; melatonin; mitochondria; oxidative stress; aging
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MDPI and ACS Style

Rusanova, I.; Martínez-Ruiz, L.; Florido, J.; Rodríguez-Santana, C.; Guerra-Librero, A.; Acuña-Castroviejo, D.; Escames, G. Protective Effects of Melatonin on the Skin: Future Perspectives. Int. J. Mol. Sci. 2019, 20, 4948. https://doi.org/10.3390/ijms20194948

AMA Style

Rusanova I, Martínez-Ruiz L, Florido J, Rodríguez-Santana C, Guerra-Librero A, Acuña-Castroviejo D, Escames G. Protective Effects of Melatonin on the Skin: Future Perspectives. International Journal of Molecular Sciences. 2019; 20(19):4948. https://doi.org/10.3390/ijms20194948

Chicago/Turabian Style

Rusanova, Iryna, Laura Martínez-Ruiz, Javier Florido, César Rodríguez-Santana, Ana Guerra-Librero, Darío Acuña-Castroviejo, and Germaine Escames. 2019. "Protective Effects of Melatonin on the Skin: Future Perspectives" International Journal of Molecular Sciences 20, no. 19: 4948. https://doi.org/10.3390/ijms20194948

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