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Open AccessArticle

Fluorescent Radiosensitizing Gold Nanoparticles

1
Institut Univers, Temps-fréquence, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UTINAM), UMR 6213 CNRS-UBFC, Université Bourgogne Franche-Comté, 25030 Besançon CEDEX, France
2
Institut des Sciences Moléculaires d’Orsay, UMR 8214 CNRS-UPS, Université Paris-Sud, 91405 Orsay CEDEX, France
3
Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, UMR 7369 CNRS-URCA, Université de Reims Champagne-Ardenne, 51687 Reims CEDEX 2, France
4
Centre de Recherche en Automatique de Nancy, Département Biologie, Signaux et Systèmes en Cancérologie et Neurosciences, UMR 7039 CNRS-UL, Université de Lorraine, 54505 Vandœuvre-lès-Nancy, France
5
CheMatech, 21000 Dijon, France
6
Institut de Chimie Moléculaire de l’Université de Bourgogne (ICMUB), UMR 6302 CNRS-UBFC, Université Bourgogne Franche-Comté, 21078 Dijon CEDEX, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4618; https://doi.org/10.3390/ijms20184618
Received: 31 August 2019 / Revised: 16 September 2019 / Accepted: 16 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Nanoparticle-Based Radiosensitization)
Ultrasmall polyaminocarboxylate-coated gold nanoparticles (NPs), [email protected] and [email protected], that have been recently developed exhibit a promising potential for image-guided radiotherapy. In order to render the radiosensitizing effect of these gold nanoparticles even more efficient, the study of their localization in cells is required to better understand the relation between the radiosensitizing properties of the agents and their localization in cells and in tumors. To achieve this goal, post-functionalization of [email protected] nanoparticles by near-infrared (NIF) organic dyes (aminated derivative of cyanine 5, Cy5-NH2) was performed. The immobilization of organic Cy5-NH2 dyes onto the gold nanoparticles confers to these radiosensitizers fluorescence properties which can be exploited for monitoring their internalization in cancerous cells, for determining their localization in cells by fluorescence microscopy (a common and powerful imaging tool in biology), and for following up on their accumulation in tumors after intravenous injection. View Full-Text
Keywords: gold nanoparticles; radiosensitization; fluorescence imaging gold nanoparticles; radiosensitization; fluorescence imaging
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MDPI and ACS Style

Jiménez Sánchez, G.; Maury, P.; Stefancikova, L.; Campion, O.; Laurent, G.; Chateau, A.; Bouraleh Hoch, F.; Boschetti, F.; Denat, F.; Pinel, S.; Devy, J.; Porcel, E.; Lacombe, S.; Bazzi, R.; Roux, S. Fluorescent Radiosensitizing Gold Nanoparticles. Int. J. Mol. Sci. 2019, 20, 4618.

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