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Noncanonical Ion Channel Behaviour in Pain

Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria
Wolfson Centre for Age-Related Diseases, King’s College London, London SE1 1UR, UK
Institute of Physiology, University Hospital RWTH Aachen, 52074 Aachen, Germany
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(18), 4572;
Received: 7 August 2019 / Revised: 9 September 2019 / Accepted: 12 September 2019 / Published: 15 September 2019
(This article belongs to the Special Issue Ion Channels of Nociception)
Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Primarily considering ion channels involved in the nociceptive system, this review covers more novel and less known features. Accordingly, we outline noncanonical operation of voltage-gated sodium, potassium, transient receptor potential (TRP), and hyperpolarization-activated cyclic nucleotide (HCN)-gated channels. Noncanonical features discussed include properties as a memory for prior voltage and chemical exposure, alternative ion conduction pathways, cluster formation, and silent subunits. Complementary to this main focus, the intention is also to transfer knowledge between fields, which become inevitably more separate due to their size. View Full-Text
Keywords: pharmacology; drug development; sodium channel; potassium channel; TRP channel; HCN channel pharmacology; drug development; sodium channel; potassium channel; TRP channel; HCN channel
MDPI and ACS Style

Ciotu, C.I.; Tsantoulas, C.; Meents, J.; Lampert, A.; McMahon, S.B.; Ludwig, A.; Fischer, M.J. Noncanonical Ion Channel Behaviour in Pain. Int. J. Mol. Sci. 2019, 20, 4572.

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