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MicroRNA Networks Modulate Oxidative Stress in Cancer

Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan
Int. J. Mol. Sci. 2019, 20(18), 4497; https://doi.org/10.3390/ijms20184497
Received: 20 August 2019 / Revised: 6 September 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
Imbalanced regulation of reactive oxygen species (ROS) and antioxidant factors in cells is known as “oxidative stress (OS)”. OS regulates key cellular physiological responses through signal transduction, transcription factors and noncoding RNAs (ncRNAs). Increasing evidence indicates that continued OS can cause chronic inflammation, which in turn contributes to cardiovascular and neurological diseases and cancer development. MicroRNAs (miRNAs) are small ncRNAs that produce functional 18-25-nucleotide RNA molecules that play critical roles in the regulation of target gene expression by binding to complementary regions of the mRNA and regulating mRNA degradation or inhibiting translation. Furthermore, miRNAs function as either tumor suppressors or oncogenes in cancer. Dysregulated miRNAs reportedly modulate cancer hallmarks such as metastasis, angiogenesis, apoptosis and tumor growth. Notably, miRNAs are involved in ROS production or ROS-mediated function. Accordingly, investigating the interaction between ROS and miRNAs has become an important endeavor that is expected to aid in the development of effective treatment/prevention strategies for cancer. This review provides a summary of the essential properties and functional roles of known miRNAs associated with OS in cancers. View Full-Text
Keywords: oxidative stress; MicroRNA; signal transduction; therapeutic target oxidative stress; MicroRNA; signal transduction; therapeutic target
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Lin, Y.-H. MicroRNA Networks Modulate Oxidative Stress in Cancer. Int. J. Mol. Sci. 2019, 20, 4497.

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