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Promising Cytomegalovirus-Based Vaccine Vector Induces Robust CD8+ T-Cell Response

1
School of Biological Sciences and Biotechnology, Minnan Normal University, Zhangzhou 363000, China
2
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers—New Jersey Medical School, Newark, NJ 07103, USA
3
Department of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA
4
College of Life Sciences, Jinan University, Guangzhou 510632, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4457; https://doi.org/10.3390/ijms20184457
Received: 14 August 2019 / Revised: 5 September 2019 / Accepted: 9 September 2019 / Published: 10 September 2019
Vaccination has had great success in combating diseases, especially infectious diseases. However, traditional vaccination strategies are ineffective for several life-threatening diseases, including acquired immunodeficiency syndrome (AIDS), tuberculosis, malaria, and cancer. Viral vaccine vectors represent a promising strategy because they can efficiently deliver foreign genes and enhance antigen presentation in vivo. However, several limitations, including pre-existing immunity and packaging capacity, block the application of viral vectors. Cytomegalovirus (CMV) has been demonstrated as a new type of viral vector with additional advantages. CMV could systematically elicit and maintain high frequencies of effector memory T cells through the “memory inflation” mechanism. Studies have shown that CMV can be genetically modified to induce distinct patterns of CD8+ T-cell responses, while some unconventional CD8+ T-cell responses are rarely induced through conventional vaccine strategies. CMV has been used as a vaccine vector to deliver many disease-specific antigens, and the efficacy of these vaccines was tested in different animal models. Promising results demonstrated that the robust and unconventional T-cell responses elicited by the CMV-based vaccine vector are essential to control these diseases. These accumulated data and evidence strongly suggest that a CMV-based vaccine vector represents a promising approach to develop novel prophylactic and therapeutic vaccines against some epidemic pathogens and tumors. View Full-Text
Keywords: cytomegalovirus; CMV; HCMV; vaccine vector; T-cell response; vaccine strategy; animal model; disease control cytomegalovirus; CMV; HCMV; vaccine vector; T-cell response; vaccine strategy; animal model; disease control
MDPI and ACS Style

Liu, J.; Jaijyan, D.K.; Tang, Q.; Zhu, H. Promising Cytomegalovirus-Based Vaccine Vector Induces Robust CD8+ T-Cell Response. Int. J. Mol. Sci. 2019, 20, 4457.

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