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Promising Cytomegalovirus-Based Vaccine Vector Induces Robust CD8+ T-Cell Response

School of Biological Sciences and Biotechnology, Minnan Normal University, Zhangzhou 363000, China
Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers—New Jersey Medical School, Newark, NJ 07103, USA
Department of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA
College of Life Sciences, Jinan University, Guangzhou 510632, China
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4457;
Received: 14 August 2019 / Revised: 5 September 2019 / Accepted: 9 September 2019 / Published: 10 September 2019
Vaccination has had great success in combating diseases, especially infectious diseases. However, traditional vaccination strategies are ineffective for several life-threatening diseases, including acquired immunodeficiency syndrome (AIDS), tuberculosis, malaria, and cancer. Viral vaccine vectors represent a promising strategy because they can efficiently deliver foreign genes and enhance antigen presentation in vivo. However, several limitations, including pre-existing immunity and packaging capacity, block the application of viral vectors. Cytomegalovirus (CMV) has been demonstrated as a new type of viral vector with additional advantages. CMV could systematically elicit and maintain high frequencies of effector memory T cells through the “memory inflation” mechanism. Studies have shown that CMV can be genetically modified to induce distinct patterns of CD8+ T-cell responses, while some unconventional CD8+ T-cell responses are rarely induced through conventional vaccine strategies. CMV has been used as a vaccine vector to deliver many disease-specific antigens, and the efficacy of these vaccines was tested in different animal models. Promising results demonstrated that the robust and unconventional T-cell responses elicited by the CMV-based vaccine vector are essential to control these diseases. These accumulated data and evidence strongly suggest that a CMV-based vaccine vector represents a promising approach to develop novel prophylactic and therapeutic vaccines against some epidemic pathogens and tumors. View Full-Text
Keywords: cytomegalovirus; CMV; HCMV; vaccine vector; T-cell response; vaccine strategy; animal model; disease control cytomegalovirus; CMV; HCMV; vaccine vector; T-cell response; vaccine strategy; animal model; disease control
MDPI and ACS Style

Liu, J.; Jaijyan, D.K.; Tang, Q.; Zhu, H. Promising Cytomegalovirus-Based Vaccine Vector Induces Robust CD8+ T-Cell Response. Int. J. Mol. Sci. 2019, 20, 4457.

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