Next Article in Journal
Mast Cell Responses to Viruses and Pathogen Products
Next Article in Special Issue
Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials
Previous Article in Journal
Vine Waste Valorisation: Integrated Approach for the Prospection of Bioactive Lipophilic Phytochemicals
Previous Article in Special Issue
Marine-Derived Omega-3 Polyunsaturated Fatty Acids and Heart Failure: Current Understanding for Basic to Clinical Relevance
Open AccessReview

Omega-3 Docosahexaenoic Acid Is a Mediator of Fate-Decision of Adult Neural Stem Cells

Univ-Lyon, Inserm UMR 1060, Inra UMR 1397, IMBL, INSA-Lyon, 69100 Villeurbanne, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(17), 4240; https://doi.org/10.3390/ijms20174240
Received: 29 July 2019 / Revised: 26 August 2019 / Accepted: 27 August 2019 / Published: 30 August 2019
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Disease: New Knowledge 2019)
The mammalian brain is enriched with lipids that serve as energy catalyzers or secondary messengers of essential signaling pathways. Docosahexaenoic acid (DHA) is an omega-3 fatty acid synthesized de novo at low levels in humans, an endogenous supply from its precursors, and is mainly incorporated from nutrition, an exogeneous supply. Decreased levels of DHA have been reported in the brains of patients with neurodegenerative diseases. Preventing this decrease or supplementing the brain with DHA has been considered as a therapy for the DHA brain deficiency that could be linked with neuronal death or neurodegeneration. The mammalian brain has, however, a mechanism of compensation for loss of neurons in the brain: neurogenesis, the birth of neurons from neural stem cells. In adulthood, neurogenesis is still present, although at a slower rate and with low efficiency, where most of the newly born neurons die. Neural stem/progenitor cells (NSPCs) have been shown to require lipids for proper metabolism for proliferation maintenance and neurogenesis induction. Recent studies have focused on the effects of these essential lipids on the neurobiology of NSPCs. This review aimed to introduce the possible use of DHA to impact NSPC fate-decision as a therapy for neurodegenerative diseases. View Full-Text
Keywords: omega-3 fatty acids; docosahexaenoic acid; neural stem cell; adult neurogenesis; neuroprotection omega-3 fatty acids; docosahexaenoic acid; neural stem cell; adult neurogenesis; neuroprotection
Show Figures

Figure 1

MDPI and ACS Style

Lo Van, A.; Hachem, M.; Lagarde, M.; Bernoud-Hubac, N. Omega-3 Docosahexaenoic Acid Is a Mediator of Fate-Decision of Adult Neural Stem Cells. Int. J. Mol. Sci. 2019, 20, 4240.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop