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Review

Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties

1
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
2
Key Laboratory of Sustainable Development of Polar Fisheries, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences; Laboratory for Marine Drugs and Byproducts of Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266071, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(17), 4238; https://doi.org/10.3390/ijms20174238
Received: 17 July 2019 / Revised: 14 August 2019 / Accepted: 18 August 2019 / Published: 30 August 2019
(This article belongs to the Section Bioactives and Nutraceuticals)
Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the two diterpenes demonstrate multiple potential pharmacological actions such as anti-inflammation, hepatoprotective, anti-cancer, anti-diabetic, and anti-osteoclastogenesis activities. The most relevant mechanisms involved are down-regulating inflammation mediators, increasing glutathione (GSH), inducing apoptosis of tumor cells and anti-angiogenesis. Cafestol and kahweol show similar biological activities but not exactly the same, which might due to the presence of one conjugated double bond on the furan ring of the latter. This review aims to summarize the pharmacological properties and the underlying mechanisms of cafestol-type diterpenoids, which show their potential as functional food and multi-target alternative medicine. View Full-Text
Keywords: cafestol; kahweol; serum lipid; anti-inflammation; anti-tumor; anti-diabetes cafestol; kahweol; serum lipid; anti-inflammation; anti-tumor; anti-diabetes
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MDPI and ACS Style

Ren, Y.; Wang, C.; Xu, J.; Wang, S. Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. Int. J. Mol. Sci. 2019, 20, 4238. https://doi.org/10.3390/ijms20174238

AMA Style

Ren Y, Wang C, Xu J, Wang S. Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. International Journal of Molecular Sciences. 2019; 20(17):4238. https://doi.org/10.3390/ijms20174238

Chicago/Turabian Style

Ren, Yaqi, Chunlan Wang, Jiakun Xu, and Shuaiyu Wang. 2019. "Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties" International Journal of Molecular Sciences 20, no. 17: 4238. https://doi.org/10.3390/ijms20174238

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