Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling
1
Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
2
Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan
3
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
4
Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
5
Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan
6
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(16), 3913; https://doi.org/10.3390/ijms20163913
Received: 20 July 2019
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Revised: 8 August 2019
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Accepted: 9 August 2019
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Published: 12 August 2019
(This article belongs to the Special Issue Motile Function of Myosins in Cells and Tissues)
Recent findings have revealed the role of membrane traffic in the signaling of transforming growth factor-β (TGF-β). These findings originate from the pivotal function of TGF-β in development, cell proliferation, tumor metastasis, and many other processes essential in malignancy. Actin and unconventional myosin have crucial roles in subcellular trafficking of receptors; research has also revealed a growing number of unconventional myosins that have crucial roles in TGF-β signaling. Unconventional myosins modulate the spatial organization of endocytic trafficking and tether membranes or transport them along the actin cytoskeletons. Current models do not fully explain how membrane traffic forms a bridge between TGF-β and the downstream effectors that produce its functional responsiveness, such as cell migration. In this review, we present a brief overview of the current knowledge of the TGF-β signaling pathway and the molecular components that comprise the core pathway as follows: ligands, receptors, and Smad mediators. Second, we highlight key role(s) of myosin motor-mediated protein trafficking and membrane domain segregation in the modulation of the TGF-β signaling pathway. Finally, we review future challenges and provide future prospects in this field.
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Keywords:
unconventional myosin; TGF-β; endocytosis; subcellular trafficking; lipid-rafts; clathrin-coated pits
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MDPI and ACS Style
Chung, C.-L.; Tai, S.-B.; Hu, T.-H.; Chen, J.-J.; Chen, C.-L. Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling. Int. J. Mol. Sci. 2019, 20, 3913. https://doi.org/10.3390/ijms20163913
AMA Style
Chung C-L, Tai S-B, Hu T-H, Chen J-J, Chen C-L. Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling. International Journal of Molecular Sciences. 2019; 20(16):3913. https://doi.org/10.3390/ijms20163913
Chicago/Turabian StyleChung, Chih-Ling, Shun-Ban Tai, Tsung-Hui Hu, Jih-Jung Chen, and Chun-Lin Chen. 2019. "Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling" International Journal of Molecular Sciences 20, no. 16: 3913. https://doi.org/10.3390/ijms20163913
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