Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling
AbstractRecent findings have revealed the role of membrane traffic in the signaling of transforming growth factor-β (TGF-β). These findings originate from the pivotal function of TGF-β in development, cell proliferation, tumor metastasis, and many other processes essential in malignancy. Actin and unconventional myosin have crucial roles in subcellular trafficking of receptors; research has also revealed a growing number of unconventional myosins that have crucial roles in TGF-β signaling. Unconventional myosins modulate the spatial organization of endocytic trafficking and tether membranes or transport them along the actin cytoskeletons. Current models do not fully explain how membrane traffic forms a bridge between TGF-β and the downstream effectors that produce its functional responsiveness, such as cell migration. In this review, we present a brief overview of the current knowledge of the TGF-β signaling pathway and the molecular components that comprise the core pathway as follows: ligands, receptors, and Smad mediators. Second, we highlight key role(s) of myosin motor-mediated protein trafficking and membrane domain segregation in the modulation of the TGF-β signaling pathway. Finally, we review future challenges and provide future prospects in this field. View Full-Text
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Chung, C.-L.; Tai, S.-B.; Hu, T.-H.; Chen, J.-J.; Chen, C.-L. Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling. Int. J. Mol. Sci. 2019, 20, 3913.
Chung C-L, Tai S-B, Hu T-H, Chen J-J, Chen C-L. Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling. International Journal of Molecular Sciences. 2019; 20(16):3913.Chicago/Turabian Style
Chung, Chih-Ling; Tai, Shun-Ban; Hu, Tsung-Hui; Chen, Jih-Jung; Chen, Chun-Lin. 2019. "Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling." Int. J. Mol. Sci. 20, no. 16: 3913.
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