Next Article in Journal
Nitrogen Fertilizer Induced Alterations in The Root Proteome of Two Rice Cultivars
Next Article in Special Issue
Structural Mapping of Missense Mutations in the Pex1/Pex6 Complex
Previous Article in Journal
Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies
Open AccessReview

Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease

Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, KU Leuven—University of Leuven, 3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3673; https://doi.org/10.3390/ijms20153673
Received: 28 June 2019 / Revised: 24 July 2019 / Accepted: 25 July 2019 / Published: 26 July 2019
(This article belongs to the Special Issue Peroxisomes under the Spotlight: Collaboration is the Way to Go)
Hydrogen peroxide (H2O2), a non-radical reactive oxygen species generated during many (patho)physiological conditions, is currently universally recognized as an important mediator of redox-regulated processes. Depending on its spatiotemporal accumulation profile, this molecule may act as a signaling messenger or cause oxidative damage. The focus of this review is to comprehensively evaluate the evidence that peroxisomes, organelles best known for their role in cellular lipid metabolism, also serve as hubs in the H2O2 signaling network. We first briefly introduce the basic concepts of how H2O2 can drive cellular signaling events. Next, we outline the peroxisomal enzyme systems involved in H2O2 metabolism in mammals and reflect on how this oxidant can permeate across the organellar membrane. In addition, we provide an up-to-date overview of molecular targets and biological processes that can be affected by changes in peroxisomal H2O2 metabolism. Where possible, emphasis is placed on the molecular mechanisms and factors involved. From the data presented, it is clear that there are still numerous gaps in our knowledge. Therefore, gaining more insight into how peroxisomes are integrated in the cellular H2O2 signaling network is of key importance to unravel the precise role of peroxisomal H2O2 production and scavenging in normal and pathological conditions. View Full-Text
Keywords: peroxisomes; flavin oxidases; catalase; hydrogen peroxide; cysteine oxidation; redox signaling; oxidative stress; organelle dysfunction; human disease peroxisomes; flavin oxidases; catalase; hydrogen peroxide; cysteine oxidation; redox signaling; oxidative stress; organelle dysfunction; human disease
Show Figures

Graphical abstract

MDPI and ACS Style

Lismont, C.; Revenco, I.; Fransen, M. Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease. Int. J. Mol. Sci. 2019, 20, 3673.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop