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Nervous-Like Circuits in the Ribosome Facts, Hypotheses and Perspectives
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Proteomic Techniques to Examine Neuronal Translational Dynamics

Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32601, USA
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(14), 3524; https://doi.org/10.3390/ijms20143524
Received: 17 June 2019 / Revised: 8 July 2019 / Accepted: 15 July 2019 / Published: 18 July 2019
(This article belongs to the Special Issue Structure, Function and Evolution of the Ribosome)
Impairments in translation have been increasingly implicated in the pathogenesis and progression of multiple neurodegenerative diseases. Assessing the spatiotemporal dynamics of translation in the context of disease is a major challenge. Recent developments in proteomic analyses have enabled the resolution of nascent peptides in a short timescale on the order of minutes. In addition, a quantitative analysis of translation has progressed in vivo, showing remarkable potential for coupling these techniques with cognitive and behavioral outcomes. Here, we review these modern approaches to measure changes in translation and ribosomal function with a specific focus on current applications in the mammalian brain and in the study of neurodegenerative diseases. View Full-Text
Keywords: nascent proteomics; ribosome; neurodegeneration; translation; Alzheimer’s disease nascent proteomics; ribosome; neurodegeneration; translation; Alzheimer’s disease
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Koren, S.A.; Gillett, D.A.; D’Alton, S.V.; Hamm, M.J.; Abisambra, J.F. Proteomic Techniques to Examine Neuronal Translational Dynamics. Int. J. Mol. Sci. 2019, 20, 3524.

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