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NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis

Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University o of Brescia, Viale Europa, 25123 Brescia, Italy
Interdipartimental University Center of Research, Adaption and Regeneration of Tissues and Organs (ARTO), University of Brescia, 25123 Brescia, Italy
Laboratory of Molecular Biology Applied to Nephrology, Experimental Research Center, Hospital de Clínicas de Porto Alegre, 90035-903 Porto Alegre, Brazil
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(14), 3466;
Received: 14 June 2019 / Revised: 2 July 2019 / Accepted: 10 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Bioactive and Uremic Toxins in Chronic Kidney Disease)
Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). NLRP3 inflammasome activation is implicated in LN pathogenesis, suggesting its potential targets for LN treatment. Melatonin, an endogenous indoleamine, is considered an important multitasking molecule that has been reported to have anti-inflammatory effects by inhibiting nuclear factor-kappa B (NF-κB)-mediated inflammatory responses in vivo. This molecule has also protective effects against the activation of the inflammasomes and, in particular, the NLRP3 inflammasome. Thus, this work evaluated the effect of melatonin on morphological alteration and NLRP3 inflammasome activation in LN pristane mouse models. To evaluate the melatonin effects in these mice, we studied the renal cytoarchitecture by means of morphological analyses and immunohistochemical expression of specific markers related to oxidative stress, inflammation and inflammasome activation. Our results showed that melatonin attenuates pristane-induced LN through restoring of morphology and attenuation of oxidative stress and inflammation through a pathway that inhibited activation of NLRP3 inflammasome signaling. Our data clearly demonstrate that melatonin has protective activity on lupus nephritis in these mice that is highly associated with its effect on enhancing the Nrf2 antioxidant signaling pathway and decreasing renal NLRP3 inflammasome activation. View Full-Text
Keywords: Lupus nephritis; oxidative stress; inflammation; melatonin Lupus nephritis; oxidative stress; inflammation; melatonin
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MDPI and ACS Style

Bonomini, F.; Dos Santos, M.; Veronese, F.V.; Rezzani, R. NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis. Int. J. Mol. Sci. 2019, 20, 3466.

AMA Style

Bonomini F, Dos Santos M, Veronese FV, Rezzani R. NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis. International Journal of Molecular Sciences. 2019; 20(14):3466.

Chicago/Turabian Style

Bonomini, Francesca, Mariane Dos Santos, Francisco Veríssimo Veronese, and Rita Rezzani. 2019. "NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis" International Journal of Molecular Sciences 20, no. 14: 3466.

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