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Open AccessArticle

Bifidobacterium and Lactobacillus Composition at Species Level and Gut Microbiota Diversity in Infants before 6 Weeks

by Bo Yang 1,2,3, Yingqi Chen 1,2, Catherine Stanton 3,4,5, 3,5, Yuan-Kun Lee 3,6, Jianxin Zhao 1,2,3, Hao Zhang 1,2,7 and Wei Chen 1,2,7,8,*
1
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
2
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
3
International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214122, China
4
Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Co. Cork, Ireland
5
APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland
6
Department of Microbiology and Immunology, National University of Singapore, Singapore 117545, Singapore
7
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
8
Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 102488, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3306; https://doi.org/10.3390/ijms20133306
Received: 5 June 2019 / Revised: 1 July 2019 / Accepted: 4 July 2019 / Published: 5 July 2019
(This article belongs to the Section Molecular Microbiology)
Our objective was to investigate the effects of different delivery and feeding modes on the gut microbiota composition of early infants with special emphasis on Bifidobacterium and Lactobacillus profiles at species level. 16S rRNA V3-V4 regions, bifidobacterial, and lactobacilli groEL genes from infant feces were sequenced by Illumina MiSeq. Gut microbiota abundance was significantly different, where standard vaginally delivered (SVD) and breast-fed (BF) groups were higher in comparison with caesarean section (CS), milk-powder-fed (MPF), and mixed-fed (MF) groups. The genus unclassified Enterobacteriaceae was dominant, followed by Bifidobacterium, which was highly abundant in SVD and BF groups. The dominant Bifidobacterium species in all groups were B. longum subsp. longum, B. longum subsp. infantis and B. animalis subsp. lactis. B. dentium and the diversity of Bifidobacterium in SVD and BF groups were significantly higher. For Lactobacillus profiles, L. rhamnosus and L. gasseri were dominant among all the groups, while Lactobacillus species in CS and MPF groups were more diverse. Functional predictions showed significant differences between delivery mode and feeding groups, such as phosphotransferase system as well as taurine and hypotaurine metabolism. In early infants with different delivery and feeding methods, gut microbiota—particularly bifidobacteria and lactobacilli communities—showed significant differences, with strong implications for physiological functions. View Full-Text
Keywords: gut microbiota; Bifidobacterium communities; Lactobacillus communities; diversity; infants; functional prediction gut microbiota; Bifidobacterium communities; Lactobacillus communities; diversity; infants; functional prediction
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Yang, B.; Chen, Y.; Stanton, C.; Ross, R.P.; Lee, Y.-K.; Zhao, J.; Zhang, H.; Chen, W. Bifidobacterium and Lactobacillus Composition at Species Level and Gut Microbiota Diversity in Infants before 6 Weeks. Int. J. Mol. Sci. 2019, 20, 3306.

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