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Graphene Optical Biosensors
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Graphene- and Graphene Oxide-Based Nanocomposite Platforms for Electrochemical Biosensing Applications

1
Nanophotonics and Metrology Laboratory (NAM), Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland
2
Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
3
Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
4
School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia
5
Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 2975; https://doi.org/10.3390/ijms20122975
Received: 24 April 2019 / Revised: 1 June 2019 / Accepted: 4 June 2019 / Published: 18 June 2019
(This article belongs to the Special Issue Graphene: Biological Applications)
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Abstract

Graphene and its derivatives such as graphene oxide (GO) and reduced GO (rGO) offer excellent electrical, mechanical and electrochemical properties. Further, due to the presence of high surface area, and a rich oxygen and defect framework, they are able to form nanocomposites with metal/semiconductor nanoparticles, metal oxides, quantum dots and polymers. Such nanocomposites are becoming increasingly useful as electrochemical biosensing platforms. In this review, we present a brief introduction on the aforementioned graphene derivatives, and discuss their synthetic strategies and structure–property relationships important for biosensing. We then highlight different nanocomposite platforms that have been developed for electrochemical biosensing, introducing enzymatic biosensors, followed by non-enzymatic biosensors and immunosensors. Additionally, we briefly discuss their role in the emerging field of biomedical cell capture. Finally, a brief outlook on these topics is presented. View Full-Text
Keywords: graphene; graphene oxide; reduced graphene oxide; electrochemical biosensor; cell capture graphene; graphene oxide; reduced graphene oxide; electrochemical biosensor; cell capture
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Thangamuthu, M.; Hsieh, K.Y.; Kumar, P.V.; Chen, G.-Y. Graphene- and Graphene Oxide-Based Nanocomposite Platforms for Electrochemical Biosensing Applications. Int. J. Mol. Sci. 2019, 20, 2975.

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