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Molecular-Based Treatment Strategies for Osteoporosis: A Literature Review

Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Int. J. Mol. Sci. 2019, 20(10), 2557; https://doi.org/10.3390/ijms20102557
Received: 25 April 2019 / Revised: 21 May 2019 / Accepted: 22 May 2019 / Published: 24 May 2019
(This article belongs to the Special Issue Osteoporosis: From Molecular Mechanisms to Therapies)
Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-resorptive agents (calcitonin, estrogen, and selective estrogen-receptor modulators, bisphosphonates, anti-receptor activator of nuclear factor κB ligand antibody along with calcium and vitamin D supplementations) and anabolic agents (parathyroid hormone and related peptide analogs, sclerostin inhibitors) have major roles in current treatment regimens and are used alone or in combination based on the pathological condition. Recent advancements in the molecular understanding of bone metabolism and in bioengineering will open the door to future treatment paradigms for osteoporosis, including antibody agents, stem cells, and gene therapies. This review provides an overview of the molecular mechanisms, clinical evidence, and potential adverse effects of drugs that are currently used or under development for the treatment of osteoporosis to aid clinicians in deciding how to select the best treatment option. View Full-Text
Keywords: osteoporosis; bone metabolism; osteoblast; osteoclast; bisphosphonate; parathyroid hormone; calcitonin; receptor activator of nuclear factor κB; sclerostin; stem cell osteoporosis; bone metabolism; osteoblast; osteoclast; bisphosphonate; parathyroid hormone; calcitonin; receptor activator of nuclear factor κB; sclerostin; stem cell
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MDPI and ACS Style

Ukon, Y.; Makino, T.; Kodama, J.; Tsukazaki, H.; Tateiwa, D.; Yoshikawa, H.; Kaito, T. Molecular-Based Treatment Strategies for Osteoporosis: A Literature Review. Int. J. Mol. Sci. 2019, 20, 2557.

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