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Open AccessReview

Updates on Aptamer Research

Center for Aging and Associated Diseases, Zewail City of Science and Technology, Giza 12578, Egypt
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-5215, USA
Department of Pharmacology and Toxicology, Ahram Canadian University, 6th of October City, Giza 12566, Egypt
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(10), 2511;
Received: 27 March 2019 / Revised: 26 April 2019 / Accepted: 30 April 2019 / Published: 21 May 2019
(This article belongs to the Section Molecular Biology)
For many years, different probing techniques have mainly relied on antibodies for molecular recognition. However, with the discovery of aptamers, this has changed. The science community is currently considering using aptamers in molecular targeting studies because of the many potential advantages they have over traditional antibodies. Some of these possible advantages are their specificity, higher binding affinity, better target discrimination, minimized batch-to-batch variation, and reduced side effects. Overall, these characteristics of aptamers have attracted scholars to use them as molecular probes in place of antibodies, with some aptamer-based targeting products being now available in the market. The present review is aimed at discussing the potential of aptamers as probes in molecular biology and in super-resolution microscopy. View Full-Text
Keywords: aptamer; SELEX; antibodies; nanobodies; super-resolution microscopy aptamer; SELEX; antibodies; nanobodies; super-resolution microscopy
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Ali, M.H.; Elsherbiny, M.E.; Emara, M. Updates on Aptamer Research. Int. J. Mol. Sci. 2019, 20, 2511.

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