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Mesenchymal Stem Cells—Potential Applications in Kidney Diseases

1
Psychiatric Services of Thurgovia, Academic Teaching Hospital of the Medical University of Salzburg, 8596 Münsterlingen, Switzerland
2
General Practice, 43-426 Dębowiec, Poland
3
Regional Blood Donation and Blood Treatment Centre, 40-074 Katowice, Poland
4
DaVita Dialysis, 42-700 Lubliniec, Poland
5
Department of Internal Medicine, Diabetology and Nephrology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Int. J. Mol. Sci. 2019, 20(10), 2462; https://doi.org/10.3390/ijms20102462
Received: 29 March 2019 / Revised: 16 May 2019 / Accepted: 16 May 2019 / Published: 18 May 2019
(This article belongs to the Special Issue Kidney Inflammation, Injury and Regeneration)
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Abstract

Mesenchymal stem cells constitute a pool of cells present throughout the lifetime in numerous niches, characteristic of unlimited replication potential and the ability to differentiate into mature cells of mesodermal tissues in vitro. The therapeutic potential of these cells is, however, primarily associated with their capabilities of inhibiting inflammation and initiating tissue regeneration. Owing to these properties, mesenchymal stem cells (derived from the bone marrow, subcutaneous adipose tissue, and increasingly urine) are the subject of research in the settings of kidney diseases in which inflammation plays the key role. The most advanced studies, with the first clinical trials, apply to ischemic acute kidney injury, renal transplantation, lupus and diabetic nephropathies, in which beneficial clinical effects of cells themselves, as well as their culture medium, were observed. The study findings imply that mesenchymal stem cells act predominantly through secreted factors, including, above all, microRNAs contained within extracellular vesicles. Research over the coming years will focus on this secretome as a possible therapeutic agent void of the potential carcinogenicity of the cells. View Full-Text
Keywords: mesenchymal stem cell; mesodermal stem cell; renal ischemia-reperfusion; inflammation; kidney transplantation; microRNA; extracellular vesicles; exosomes mesenchymal stem cell; mesodermal stem cell; renal ischemia-reperfusion; inflammation; kidney transplantation; microRNA; extracellular vesicles; exosomes
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Bochon, B.; Kozubska, M.; Surygała, G.; Witkowska, A.; Kuźniewicz, R.; Grzeszczak, W.; Wystrychowski, G. Mesenchymal Stem Cells—Potential Applications in Kidney Diseases. Int. J. Mol. Sci. 2019, 20, 2462.

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