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Curcumin and Heme Oxygenase: Neuroprotection and Beyond

1
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
2
Università Cattolica del Sacro Cuore, 00168 Rome, Italy
3
Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47900 Rimini, Italy
4
Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, 00185 Rome, Italy
5
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(10), 2419; https://doi.org/10.3390/ijms20102419
Received: 10 April 2019 / Revised: 10 May 2019 / Accepted: 14 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
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Abstract

Curcumin is a natural polyphenol component of Curcuma longa Linn, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti-inflammatory pathways involved in neurodegeneration. Although its poor systemic bioavailability after oral administration and low plasma concentrations represent restrictive factors for curcumin therapeutic efficacy, innovative delivery formulations have been developed in order to overwhelm these limitations. This review provides a summary of the main findings involving the heme oxygenase/biliverdin reductase system as a valid target in mediating the potential neuroprotective properties of curcumin. Furthermore, pharmacokinetic properties and concerns about curcumin’s safety profile have been addressed. View Full-Text
Keywords: curcumin; free radicals; heme oxygenase; neuroprotection; safety profile curcumin; free radicals; heme oxygenase; neuroprotection; safety profile
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Mhillaj, E.; Tarozzi, A.; Pruccoli, L.; Cuomo, V.; Trabace, L.; Mancuso, C. Curcumin and Heme Oxygenase: Neuroprotection and Beyond. Int. J. Mol. Sci. 2019, 20, 2419.

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