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Int. J. Mol. Sci. 2018, 19(9), 2740;

The Degradation Properties of MgO Whiskers/PLLA Composite In Vitro

School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China
Key Laboratory of Display Materials and Photoelectric Device (Ministry of Education), Tianjin University of Technology, Tianjin 300384, China
Tianjin Sannie Bioengineering Technology Co., Ltd., Tianjin 300384, China
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China
Author to whom correspondence should be addressed.
Received: 14 August 2018 / Revised: 28 August 2018 / Accepted: 30 August 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Synthesis and Applications of Biopolymer Composites)
PDF [4910 KB, uploaded 13 September 2018]


In this study, composite films of stearic acid–modified magnesium oxide whiskers (Sa–w-MgO)/poly-l-lactic acid (PLLA) were prepared through solution casting, and the in vitro degradation properties and cytocompatibility of the composites with different whisker contents were investigated. The results showed that the degradation behavior of the composite samples depended significantly on the whisker content, and the degradation rate increased with the addition of MgO content. Furthermore, the degradation of the composites with higher contents of whiskers was influenced more severely by the hydrophilicity and pH value, leading to more final weight loss, but the decomposition rate decreased gradually. Furthermore, the pH value of the phosphate buffer solution (PBS) was obviously regulated by the dissolution of MgO whiskers through neutralization of the acidic product of PLLA degradation. The cytocompatibility of the composites also increased remarkably, as determined from the cell viability results, and was higher than that of PLLA at the chosen whisker content. This was beneficial for the cell affinity of the material, as it notably led to an enhanced biocompatibility of the PLLA, in favor of promoting cell proliferation, which significantly improved its bioactivity, as well. View Full-Text
Keywords: biopolymers composites; MgO whiskers; PLLA; in vitro degradation biopolymers composites; MgO whiskers; PLLA; in vitro degradation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhao, Y.; Liu, B.; Bi, H.; Yang, J.; Li, W.; Liang, H.; Liang, Y.; Jia, Z.; Shi, S.; Chen, M. The Degradation Properties of MgO Whiskers/PLLA Composite In Vitro. Int. J. Mol. Sci. 2018, 19, 2740.

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