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Pathophysiological Mechanisms of Chronic Venous Disease and Implications for Venoactive Drug Therapy
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Chronic Venous Disorders: The Dangerous, the Good, and the Diverse

Department of Biomolecular Sciences, Section of Clinical Biochemistry and Molecular Genetics, University “Carlo Bo”, 61029 Urbino, Italy
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Int. J. Mol. Sci. 2018, 19(9), 2544; https://doi.org/10.3390/ijms19092544
Received: 25 July 2018 / Revised: 20 August 2018 / Accepted: 25 August 2018 / Published: 28 August 2018
(This article belongs to the Special Issue Molecular Research on Chronic Venous Disease)
Chronic venous disorders are common vascular pathology of great medical and socioeconomic impact, characterized by a wide spectrum of clinical manifestations occurring with symptoms and/or signs that vary in type and severity. The predominant pathophysiological mechanisms of chronic venous disease start from the development of venous hypertension from shear stress and reflux, leading to endothelial dysfunction and venous wall dilatation. The altered hemodynamic transduces physical signals into harmful bio-molecular pathways, creating a vicious cycle among shear stress, proteolytic remodeling, and inflammatory processes. This intricate network is further exacerbated by the degradation of protective endothelial glycocalyx. In this special issue, at least three main aspects of these interactions are highlighted: the dangerous, the good, and the diverse, which may help to focus attention on the biomolecular mechanisms and the possible targeted therapy of chronic venous disorders (CVeD). View Full-Text
Keywords: chronic venous disorders; inflammation; venous leg ulcer; wound healing; matrix metalloproteinases; biomarkers; cytokines; glycosaminoglycan; glycocalyx; chronic venous insufficiency chronic venous disorders; inflammation; venous leg ulcer; wound healing; matrix metalloproteinases; biomarkers; cytokines; glycosaminoglycan; glycocalyx; chronic venous insufficiency
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Ligi, D.; Croce, L.; Mannello, F. Chronic Venous Disorders: The Dangerous, the Good, and the Diverse. Int. J. Mol. Sci. 2018, 19, 2544.

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