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Therapeutic Immunization against Glioblastoma

1
Epitopoietic Research Corporation ERC-The Netherlands Nistelrooisebaan 3, 5374 RE Schaijk, The Netherlands
2
ERC-Belgium Gembloux Isnes, Rue Jean Sonet 10, 5031 Isnes Belgium, Belgium
3
Cell Biology & Immunology Group, Wageningen University, 6708 PB Wageningen, The Netherlands
4
Chao Family Comprehensive Cancer Center, 101 The City Drive Bldg. 23, Route 81, Orange, CA 92868, USA
5
Department of Neurological Surgery; University of California Irvine, Irvine, CA 92697, USA
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Department of Neurology, University of California Irvine, Irvine, CA 92697, USA
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Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
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Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
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Department of Molecular, Cell, and Systems Biology, University of California, Riverside, CA 92521, USA
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Department of Neurosurgery, Euroclinics Hospital, 11521 Athens, Greece
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2540; https://doi.org/10.3390/ijms19092540
Received: 14 July 2018 / Revised: 18 August 2018 / Accepted: 23 August 2018 / Published: 27 August 2018
Glioblastoma is the most common form of brain cancer in adults that produces severe damage to the brain leading to a very poor survival prognosis. The standard of care for glioblastoma is usually surgery, as well as radiotherapy followed by systemic temozolomide chemotherapy, resulting in a median survival time of about 12 to 15 months. Despite these therapeutic efforts, the tumor returns in the vast majority of patients. When relapsing, statistics suggest an imminent death dependent on the size of the tumor, the Karnofsky Performance Status, and the tumor localization. Following the standard of care, the administration of Bevacizumab, inhibiting the growth of the tumor vasculature, is an approved medicinal treatment option approved in the United States, but not in the European Union, as well as the recently approved alternating electric fields (AEFs) generator NovoTTF/Optune. However, it is clear that regardless of the current treatment regimens, glioma patients continue to have dismal prognosis and novel treatments are urgently needed. Here, we describe different approaches of recently developed therapeutic glioma brain cancer vaccines, which stimulate the patient’s immune system to recognize tumor-associated antigens (TAA) on cancer cells, aiming to instruct the immune system to eventually attack and destroy the brain tumor cells, with minimal bystander damage to normal brain cells. These distinct immunotherapies may target particular glioma TAAs which are molecularly defined, but they may also target broad patient-derived tumor antigen preparations intentionally evoking a very broad polyclonal antitumor immune stimulation. View Full-Text
Keywords: glioma tumor; brain tumor; immunotherapy; therapeutic vaccine; autologous; allogenic glioma tumor; brain tumor; immunotherapy; therapeutic vaccine; autologous; allogenic
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Schijns, V.E.J.C.; Pretto, C.; Strik, A.M.; Gloudemans-Rijkers, R.; Devillers, L.; Pierre, D.; Chung, J.; Dandekar, M.; Carrillo, J.A.; Kong, X.-T.; Fu, B.D.; Hsu, F.P.K.; Hofman, F.M.; Chen, T.C.; Zidovetzki, R.; Bota, D.A.; Stathopoulos, A. Therapeutic Immunization against Glioblastoma. Int. J. Mol. Sci. 2018, 19, 2540.

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