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Int. J. Mol. Sci. 2018, 19(8), 2352; https://doi.org/10.3390/ijms19082352

TGF-Beta Signaling in Bone with Chronic Kidney Disease

1
Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita 870-1163, Japan
2
Division of Nephrology and Metabolism, Tokai University School of Medicine, Kanagawa 259-119, Japan
*
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 30 July 2018 / Accepted: 8 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue TGF-Beta Super Family Signaling)
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Abstract

Transforming growth factor (TGF)-β signaling is not only important in skeletal development, but also essential in bone remodeling in adult bone. The bone remodeling process involves integrated cell activities induced by multiple stimuli to balance bone resorption and bone formation. TGF-β plays a role in bone remodeling by coordinating cell activities to maintain bone homeostasis. However, mineral metabolism disturbance in chronic kidney disease (CKD) results in abnormal bone remodeling, which leads to ectopic calcification in CKD. High circulating levels of humoral factors such as parathyroid hormone, fibroblast growth factor 23, and Wnt inhibitors modulate bone remodeling in CKD. Several reports have revealed that TGF-β is involved in the production and functions of these factors in bone. TGF-β may act as a factor that mediates abnormal bone remodeling in CKD. View Full-Text
Keywords: bone remodeling; mineral metabolism disturbance; chronic kidney disease; humoral factors bone remodeling; mineral metabolism disturbance; chronic kidney disease; humoral factors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Iwasaki, Y.; Yamato, H.; Fukagawa, M. TGF-Beta Signaling in Bone with Chronic Kidney Disease. Int. J. Mol. Sci. 2018, 19, 2352.

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