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Open AccessArticle

IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Post Zone C7Q, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Department of Medicine, University of Colorado, Aurora, CO 80045, USA
Department of General Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, 6525 HP Nijmegen, The Netherlands
Nutrition, Metabolism and Genomics group, Division of Human Nutrition and Health, Wageningen University, 6703 HD Wageningen, The Netherlands
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Current address: Mead Johnson Pediatric Nutrition Institute, Global R&D, 6545 CJ Nijmegen, The Netherlands.
Int. J. Mol. Sci. 2018, 19(8), 2264;
Received: 22 June 2018 / Revised: 26 July 2018 / Accepted: 31 July 2018 / Published: 2 August 2018
(This article belongs to the Section Biochemistry)
The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, inflammation and insulin resistance. The precise mechanism of action leading to these beneficial metabolic effects is not entirely known. Therefore, we aimed to assess in detail the effect of transgenic IL-37 expression on energy balance, including food intake and energy expenditure. Feeding homozygous IL-37 transgenic mice and wild-type (WT) control mice a high-fat diet (HFD; 45% kcal palm fat) for 6 weeks showed that IL-37 reduced body weight related to a marked decrease in food intake. Subsequent mechanistic studies in mice with heterozygous IL-37 expression versus WT littermates, fed the HFD for 18 weeks, confirmed that IL-37 reduces food intake, which led to a decrease in lean body mass, but did not reduce fat mass and plasma lipid levels or alterations in energy expenditure independent of lean body mass. Taken together, this suggests that IL-37 reduces lean body mass by reducing food intake. View Full-Text
Keywords: IL-37; energy metabolism; food intake; high fat diet IL-37; energy metabolism; food intake; high fat diet
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Kuipers, E.N.; Van Dam, A.D.; Ballak, D.B.; De Wit, E.A.; Dinarello, C.A.; Stienstra, R.; Van Diepen, J.A.; Rensen, P.C.; Boon, M.R. IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake. Int. J. Mol. Sci. 2018, 19, 2264.

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