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Using microRNA Networks to Understand Cancer
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The Nefarious Nexus of Noncoding RNAs in Cancer

1
HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
2
Department of Experimental Medicine, La Sapienza University, Viale Regina Elena 324, 0161 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 2072; https://doi.org/10.3390/ijms19072072
Received: 4 July 2018 / Accepted: 12 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue The Role of MicroRNAs in Human Diseases)
The past decade has witnessed enormous progress, and has seen the noncoding RNAs (ncRNAs) turn from the so-called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts. Many ncRNAs interact with each other and are part of networks that influence the cell transcriptome and proteome and consequently the outcome of biological processes. The regulatory circuits controlled by ncRNAs have become increasingly more relevant in cancer. Further understanding of these complex network interactions and how ncRNAs are regulated, is paving the way for the identification of better therapeutic strategies in cancer. View Full-Text
Keywords: noncoding RNA; miRNA; lncRNA; circRNA; ncRNA network in cancer; cancer biomarkers; RNA aided cancer therapy noncoding RNA; miRNA; lncRNA; circRNA; ncRNA network in cancer; cancer biomarkers; RNA aided cancer therapy
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Anastasiadou, E.; Faggioni, A.; Trivedi, P.; Slack, F.J. The Nefarious Nexus of Noncoding RNAs in Cancer. Int. J. Mol. Sci. 2018, 19, 2072.

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