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Recent Developments in Using Drosophila as a Model for Human Genetic Disease

Maternal Infant Child Youth and Research Network, V2-230, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada
Department of Biology, McGill University, 3649 Promenade Sir-William-Osler, Montreal, QC H3G 0B1, Canada
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 2041;
Received: 12 June 2018 / Revised: 9 July 2018 / Accepted: 10 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue Drosophila Model and Human Disease)
Many insights into human disease have been built on experimental results in Drosophila, and research in fruit flies is often justified on the basis of its predictive value for questions related to human health. Additionally, there is now a growing recognition of the value of Drosophila for the study of rare human genetic diseases, either as a means of validating the causative nature of a candidate genetic variant found in patients, or as a means of obtaining functional information about a novel disease-linked gene when there is little known about it. For these reasons, funders in the US, Europe, and Canada have launched targeted programs to link human geneticists working on discovering new rare disease loci with researchers who work on the counterpart genes in Drosophila and other model organisms. Several of these initiatives are described here, as are a number of output publications that validate this new approach. View Full-Text
Keywords: rare Mendelian diseases; animal models; targeted funding opportunities rare Mendelian diseases; animal models; targeted funding opportunities
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Oriel, C.; Lasko, P. Recent Developments in Using Drosophila as a Model for Human Genetic Disease. Int. J. Mol. Sci. 2018, 19, 2041.

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