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Review

Molecular Regulation of Differentiation in Early B-Lymphocyte Development

1
Division of Molecular Hematology, Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, 22184 Lund, Sweden
2
Department of Clinical and Experimental Medicine, Linköping University, SE-581 85 Linköping, Sweden
Int. J. Mol. Sci. 2018, 19(7), 1928; https://doi.org/10.3390/ijms19071928
Received: 30 May 2018 / Revised: 27 June 2018 / Accepted: 28 June 2018 / Published: 30 June 2018
B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isolate progenitors at defined maturation stages. The identification of defined progenitor compartments has been instrumental for the resolution of the molecular features that defines given developmental stages as well as for our understanding of the mechanisms that drive the progressive maturation process. Over the last years it has become increasingly clear that the regulatory networks that control normal B-cell differentiation are targeted by mutations in human B-lineage malignancies. This generates a most interesting link between development and disease that can be explored to improve diagnosis and treatment protocols in lymphoid malignancies. The aim of this review is to provide an overview of our current understanding of molecular regulation in normal and malignant B-cell development. View Full-Text
Keywords: B-lymphocyte; development; transcription factors; lymphoid leukemia B-lymphocyte; development; transcription factors; lymphoid leukemia
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MDPI and ACS Style

Sigvardsson, M. Molecular Regulation of Differentiation in Early B-Lymphocyte Development. Int. J. Mol. Sci. 2018, 19, 1928. https://doi.org/10.3390/ijms19071928

AMA Style

Sigvardsson M. Molecular Regulation of Differentiation in Early B-Lymphocyte Development. International Journal of Molecular Sciences. 2018; 19(7):1928. https://doi.org/10.3390/ijms19071928

Chicago/Turabian Style

Sigvardsson, Mikael. 2018. "Molecular Regulation of Differentiation in Early B-Lymphocyte Development" International Journal of Molecular Sciences 19, no. 7: 1928. https://doi.org/10.3390/ijms19071928

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