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Regulation of von-Willebrand Factor Secretion from Endothelial Cells by the Annexin A2-S100A10 Complex
Review

Annexins in Translational Research: Hidden Treasures to Be Found

Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Muenster, Von-Esmarch-Street 56, D-48149 Muenster, Germany
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Int. J. Mol. Sci. 2018, 19(6), 1781; https://doi.org/10.3390/ijms19061781
Received: 25 May 2018 / Revised: 6 June 2018 / Accepted: 12 June 2018 / Published: 15 June 2018
The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca2+) and phospholipid binding protein family which share a high structural homology. In keeping with this hallmark feature, annexins have been implicated in the Ca2+-controlled regulation of a broad range of membrane events. In this review, we identify and discuss several themes of annexin actions that hold a potential therapeutic value, namely, the regulation of the immune response and the control of tissue homeostasis, and that repeatedly surface in the annexin activity profile. Our aim is to identify and discuss those annexin properties which might be exploited from a translational science and specifically, a clinical point of view. View Full-Text
Keywords: annexins; inflammation; host-pathogen interplay; drug target; translational research annexins; inflammation; host-pathogen interplay; drug target; translational research
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MDPI and ACS Style

Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to Be Found. Int. J. Mol. Sci. 2018, 19, 1781. https://doi.org/10.3390/ijms19061781

AMA Style

Schloer S, Pajonczyk D, Rescher U. Annexins in Translational Research: Hidden Treasures to Be Found. International Journal of Molecular Sciences. 2018; 19(6):1781. https://doi.org/10.3390/ijms19061781

Chicago/Turabian Style

Schloer, Sebastian, Denise Pajonczyk, and Ursula Rescher. 2018. "Annexins in Translational Research: Hidden Treasures to Be Found" International Journal of Molecular Sciences 19, no. 6: 1781. https://doi.org/10.3390/ijms19061781

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