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Int. J. Mol. Sci. 2018, 19(5), 1445; https://doi.org/10.3390/ijms19051445

The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

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Department of Biology and Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen 518055, China
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Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
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Institute of Integrated Bioinfomedicine and Translational Science, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
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Institute of Precision Medicine and Innovative Drug Discovery, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
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Shenzhen Lab of Combinatorial Compounds and Targeted Drug Delivery, HKBU Institute of Research and Continuing Education, Shenzhen 518057, China
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Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
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Authors to whom correspondence should be addressed.
Received: 3 April 2018 / Revised: 16 April 2018 / Accepted: 17 April 2018 / Published: 12 May 2018
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [1394 KB, uploaded 12 May 2018]   |  

Abstract

Biological macromolecules are the basis of life activities. There is a separation of spatial dimension between DNA replication and RNA biogenesis, and protein synthesis, which is an interesting phenomenon. The former occurs in the cell nucleus, while the latter in the cytoplasm. The separation requires protein to transport across the nuclear envelope to realize a variety of biological functions. Nucleocytoplasmic transport of protein including import to the nucleus and export to the cytoplasm is a complicated process that requires involvement and interaction of many proteins. In recent years, many studies have found that proteins constantly shuttle between the cytoplasm and the nucleus. These shuttling proteins play a crucial role as transport carriers and signal transduction regulators within cells. In this review, we describe the mechanism of nucleocytoplasmic transport of shuttling proteins and summarize some important diseases related shuttling proteins. View Full-Text
Keywords: nucleocytoplasmic transport; shuttling protein; cancer; neurodegenerative diseases; leukemia; osteoporosis; fanconi anemia nucleocytoplasmic transport; shuttling protein; cancer; neurodegenerative diseases; leukemia; osteoporosis; fanconi anemia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Fu, X.; Liang, C.; Li, F.; Wang, L.; Wu, X.; Lu, A.; Xiao, G.; Zhang, G. The Rules and Functions of Nucleocytoplasmic Shuttling Proteins. Int. J. Mol. Sci. 2018, 19, 1445.

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