The Neurotoxic Role of Extracellular Tau Protein
Abstract
:1. Overview of Tau Protein
2. Extracellular Tau Protein
3. Molecular Mechanisms Proposed for Tau Release
4. Clearance of Extracellular Tau
5. Extracellular Tau Contributes to Synaptic Dysfunction in AD
6. Extracellular Tau Induces a Neurotoxic Effect via Muscarinic Receptor. Involvement of Tissue-Nonspecific Alkaline Phosphatase
7. Spreading of Tau Pathology
8. New Therapeutic Strategies Targeting Extracellular Tau
9. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
AD | Alzheimer’s disease |
NFTs | Neurofibrillary tangles |
CSF | cerebrospinal fluid |
MMP | matrix-metalloproteinases |
PHFs | paired helical filaments |
APP | amyloid precursor protein |
ACh | acetylcholine |
TNAP | tissue-nonspecific alkaline phosphatase |
PLP | pyridoxal 5′-phosphate |
GABA | gamma-aminobutyric acid |
CNS | central nervous system |
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Sebastián-Serrano, Á.; De Diego-García, L.; Díaz-Hernández, M. The Neurotoxic Role of Extracellular Tau Protein. Int. J. Mol. Sci. 2018, 19, 998. https://doi.org/10.3390/ijms19040998
Sebastián-Serrano Á, De Diego-García L, Díaz-Hernández M. The Neurotoxic Role of Extracellular Tau Protein. International Journal of Molecular Sciences. 2018; 19(4):998. https://doi.org/10.3390/ijms19040998
Chicago/Turabian StyleSebastián-Serrano, Álvaro, Laura De Diego-García, and Miguel Díaz-Hernández. 2018. "The Neurotoxic Role of Extracellular Tau Protein" International Journal of Molecular Sciences 19, no. 4: 998. https://doi.org/10.3390/ijms19040998