Int. J. Mol. Sci. 2018, 19(4), 995; https://doi.org/10.3390/ijms19040995
Gut Microbiota and Type 1 Diabetes
Hui Han 1,2,†, Yuying Li 1,2,†, Jun Fang 3, Gang Liu 1
, Jie Yin 1,2,*
, Tiejun Li 1,4,*
and Yulong Yin 1,4
, Jie Yin 1,2,*
, Tiejun Li 1,4,*
and Yulong Yin 1,4
1
Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China
2
University of Chinese Academy of Sciences, Beijing 100039, China
3
College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China
4
Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China
†
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 17 January 2018 / Revised: 27 February 2018 / Accepted: 2 March 2018 / Published: 27 March 2018
(This article belongs to the Special Issue The Mechanism of Action of Food Components in Disease Prevention 2017)
Abstract
Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed. View Full-TextKeywords:
gut microbiota; type 1 diabetes; diet; immune response; hormones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Han, H.; Li, Y.; Fang, J.; Liu, G.; Yin, J.; Li, T.; Yin, Y. Gut Microbiota and Type 1 Diabetes. Int. J. Mol. Sci. 2018, 19, 995.
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