Gut Microbiota and Type 1 Diabetes
1
Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China
2
University of Chinese Academy of Sciences, Beijing 100039, China
3
College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China
4
Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China
*
Authors to whom correspondence should be addressed.
†
These authors contribute equally to this work.
Int. J. Mol. Sci. 2018, 19(4), 995; https://doi.org/10.3390/ijms19040995
Received: 17 January 2018 / Revised: 27 February 2018 / Accepted: 2 March 2018 / Published: 27 March 2018
(This article belongs to the Special Issue The Mechanism of Action of Food Components in Disease Prevention 2017)
Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed.
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Keywords:
gut microbiota; type 1 diabetes; diet; immune response; hormones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Han, H.; Li, Y.; Fang, J.; Liu, G.; Yin, J.; Li, T.; Yin, Y. Gut Microbiota and Type 1 Diabetes. Int. J. Mol. Sci. 2018, 19, 995. https://doi.org/10.3390/ijms19040995
AMA Style
Han H, Li Y, Fang J, Liu G, Yin J, Li T, Yin Y. Gut Microbiota and Type 1 Diabetes. International Journal of Molecular Sciences. 2018; 19(4):995. https://doi.org/10.3390/ijms19040995
Chicago/Turabian StyleHan, Hui; Li, Yuying; Fang, Jun; Liu, Gang; Yin, Jie; Li, Tiejun; Yin, Yulong. 2018. "Gut Microbiota and Type 1 Diabetes" Int. J. Mol. Sci. 19, no. 4: 995. https://doi.org/10.3390/ijms19040995
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