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Int. J. Mol. Sci. 2018, 19(4), 1171; https://doi.org/10.3390/ijms19041171

Current Approaches Including Novel Nano/Microtechniques to Reduce Silicone Implant-Induced Contracture with Adverse Immune Responses

1
Department of Plastic and Reconstructive Surgery, Chung-Ang University Graduate School of Medicine, Seoul 06974, Korea
2
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
3
Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Kyunggi 13620, Korea
4
Department of Medical Bioscience, CHA University, Kyunggi 13488, Korea
*
Authors to whom correspondence should be addressed.
Received: 26 February 2018 / Revised: 28 March 2018 / Accepted: 10 April 2018 / Published: 12 April 2018
(This article belongs to the Special Issue Nano/Micro-Assisted Regenerative Medicine)
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Abstract

Capsular contracture, which is the pathologic development of fibrous capsules around implants, is a major complication of reconstructive and aesthetic breast surgeries. Capsular contracture can cause implant failure with breast hardening, deformity, and severe pain. The exact mechanisms underlying this complication remain unclear. In addition, anaplastic large cell lymphoma is now widely recognized as a very rare disease associated with breast implants. Foreign body reactions are an inevitable common denominator of capsular contracture. A number of studies have focused on the associated immune responses and their regulation. The present article provides an overview of the currently available techniques, including novel nano/microtechniques, to reduce silicone implant-induced contracture and associated foreign body responses. View Full-Text
Keywords: silicone breast implant; capsular contracture; foreign body reaction; T-cell immunity; ALCL; nano/microtechniques silicone breast implant; capsular contracture; foreign body reaction; T-cell immunity; ALCL; nano/microtechniques
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Kang, S.H.; Sutthiwanjampa, C.; Heo, C.Y.; Kim, W.S.; Lee, S.-H.; Park, H. Current Approaches Including Novel Nano/Microtechniques to Reduce Silicone Implant-Induced Contracture with Adverse Immune Responses. Int. J. Mol. Sci. 2018, 19, 1171.

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