Int. J. Mol. Sci. 2018, 19(4), 1137; https://doi.org/10.3390/ijms19041137
Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats
Chiang-Ting Wang 1,2, Ya-Yun Wang 3,4, Wen-Sheng Liu 5,6, Chun-Ming Cheng 7, Kuo-Hsun Chiu 6, Li-Lian Liu 8, Xue-Zhu Liu 9
, Zhi-Hong Wen 1,*
, Ya-Huey Chen 10,11,12,*
and Tsung-Ming Chen 6,*
, Zhi-Hong Wen 1,*
, Ya-Huey Chen 10,11,12,*
and Tsung-Ming Chen 6,*
1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung 80424, Taiwan
2
Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
3
Department of Chemistry, Fu Jen Catholic University, New Taipei City 24205, Taiwan
4
Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan
5
Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan
6
Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan
7
Department of Animal Pharmacology, Development Centre for Biotechnology, New Taipei City 22180, Taiwan
8
Department of Oceanography, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
9
Marine Microorganism Ecological and Application Lab, Zhejiang Ocean University, Zhoushan 316004, China
10
Graduate Institute of Biomedical Science, China Medical University, Cancer Center Building 8F, No. 6, Hsueh-shih Road, Taichung 40477, Taiwan
11
Center for Molecular Medicine, China Medical University Hospital, Taichung 40477, Taiwan
12
Cancer Biology and Drug Discovery Ph.D. Program, College of Medicine, China Medical University, Taichung 40477, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 20 February 2018 / Revised: 25 March 2018 / Accepted: 5 April 2018 / Published: 10 April 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
Abstract
Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conventional medicines cause adverse effects. Lycogen™, extracted from Rhodobacter sphaeroides WL-APD911, is an anti-oxidant and anti-inflammatory compound. In this study, the effect of Lycogen™ was evaluated in rats with testosterone-induced benign prostate hyperplasia (BPH). Testosterone injections and Lycogen™ administration were carried out for 28 days, and body weights were recorded twice per week. The testosterone injection successfully induced a prostate enlargement. BPH-induced rats treated with different doses of Lycogen™ exhibited a significantly decreased prostate index (PI). Moreover, the Lycogen™ administration recovered the histological abnormalities observed in the prostate of BPH rats. In conclusion, these findings support a dose-dependent preventing effect of Lycogen™ on testosterone-induced BPH in rats and suggest that Lycogen™ may be favorable to the prevention and management of benign prostate hyperplasia. View Full-Text
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style
Wang, C.-T.; Wang, Y.-Y.; Liu, W.-S.; Cheng, C.-M.; Chiu, K.-H.; Liu, L.-L.; Liu, X.-Z.; Wen, Z.-H.; Chen, Y.-H.; Chen, T.-M. Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats. Int. J. Mol. Sci. 2018, 19, 1137.
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