Next Article in Journal
DDX5 RNA Helicases: Emerging Roles in Viral Infection
Next Article in Special Issue
The Role of Extracellular Vesicles in Bone Metastasis
Previous Article in Journal
Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression
Previous Article in Special Issue
Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment
Open AccessReview

Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis

by Nicola Graham 1 and Bin-Zhi Qian 1,2,*
Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh EH4 2XR, UK
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 1121;
Received: 9 February 2018 / Revised: 25 March 2018 / Accepted: 29 March 2018 / Published: 9 April 2018
(This article belongs to the Special Issue Bone Metastasis: Pathophysiology and Molecular Mechanisms)
Bone metastasis is the most advanced stage of many cancers and indicates a poor prognosis for patients due to resistance to anti-tumor therapies. The establishment of metastasis within the bone is a multistep process. To ensure survival within the bone marrow, tumor cells must initially colonize a niche in which they can enter dormancy. Subsequently, reactivation permits the proliferation and growth of the tumor cells, giving rise to a macro-metastasis displayed clinically as a bone metastatic lesion. Here, we review the evidences that suggest mesenchymal stromal cells play an important role in each of these steps throughout the development of bone metastasis. Similarities between the molecular mechanisms implicated in these processes and those involved in the homeostasis of the bone indicate that the metastatic cells may exploit the homeostatic processes to their own advantage. Identifying the molecular interactions between the mesenchymal stromal cells and tumor cells that promote tumor development may offer insight into potential therapeutic targets that could be utilized to treat bone metastasis. View Full-Text
Keywords: bone; metastasis; tumor microenvironment; stromal cells; mesenchymal stem cells; cancer-associated fibroblasts; metastatic niche; dormancy bone; metastasis; tumor microenvironment; stromal cells; mesenchymal stem cells; cancer-associated fibroblasts; metastatic niche; dormancy
Show Figures

Graphical abstract

MDPI and ACS Style

Graham, N.; Qian, B.-Z. Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis. Int. J. Mol. Sci. 2018, 19, 1121.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop