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Open AccessCommunication
Int. J. Mol. Sci. 2018, 19(4), 1117; https://doi.org/10.3390/ijms19041117

Beneficial Effects of Bioactive Compounds in Mulberry Fruits against Cisplatin-Induced Nephrotoxicity

1
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea
2
College of Korean Medicine, Gachon University, Seongnam 13120, Korea
3
Advanced Bio Convergenve Center, Pohang Technopark, Pohang 37668, Korea
4
Department of Food Science, Gyeongnam National University of Science and Technology, Jinju 52725, Korea
*
Authors to whom correspondence should be addressed.
Received: 20 March 2018 / Revised: 1 April 2018 / Accepted: 4 April 2018 / Published: 9 April 2018
(This article belongs to the Section Molecular Toxicology)
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Abstract

Mulberry, the fruit of white mulberry tree (Morus alba L., Moraceae), is commonly used in traditional Chinese medicines as a sedative, tonic, laxative, and emetic. In our continuing research of the bioactive metabolites from mulberry, chemical analysis of the fruits led to the isolation of five compounds, 15. The compounds were identified as butyl pyroglutamate (1), quercetin 3-O-β-d-glucoside (2), kaempferol 3-O-β-d-rutinoside (3), rutin (4), and 2-phenylethyl d-rutinoside (5) by spectroscopic data analysis, comparing their nuclear magnetic resonance (NMR) data with those in published literature, and liquid chromatography–mass spectrometry analysis. The isolated compounds 15 were evaluated for their effects on anticancer drug-induced side effects by cell-based assays. Compound 1 exerted the highest protective effect against cisplatin-induced kidney cell damage. This effect was found to be mediated through the attenuation of phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38, mitogen-activated protein kinase, and caspase-3 in cisplatin-induced kidney cell damage. View Full-Text
Keywords: mulberry; Morus alba; cisplatin; nephrotoxicity; mitogen-activated protein kinases; caspase-3 mulberry; Morus alba; cisplatin; nephrotoxicity; mitogen-activated protein kinases; caspase-3
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lee, D.; Yu, J.S.; Lee, S.R.; Hwang, G.S.; Kang, K.S.; Park, J.G.; Kim, H.Y.; Kim, K.H.; Yamabe, N. Beneficial Effects of Bioactive Compounds in Mulberry Fruits against Cisplatin-Induced Nephrotoxicity. Int. J. Mol. Sci. 2018, 19, 1117.

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