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Int. J. Mol. Sci. 2018, 19(3), 745;

Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication

Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford OX3 7LD, UK
Center for Biomaterials, Korea Institute of Science & Technology (KIST), Seoul 02792, Korea
Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea
Author to whom correspondence should be addressed.
Received: 15 November 2017 / Revised: 26 February 2018 / Accepted: 3 March 2018 / Published: 6 March 2018
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2018)
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Electrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds for several decades. Electrospun fibrous scaffolds provide nanoscale/microscale fibrous structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential to facilitate the formation of artificial functional tissues. In this review, we summarize the fundamental principles of electrospinning processes for generating complex fibrous scaffold geometries that are similar in structural complexity to the ECM of living tissues. Moreover, several approaches for the formation of three-dimensional fibrous scaffolds arranged in hierarchical structures for tissue engineering are also presented. View Full-Text
Keywords: electrospinning; nanofiber scaffolds; tissue engineering; extracellular matrix-mimicking geometries electrospinning; nanofiber scaffolds; tissue engineering; extracellular matrix-mimicking geometries

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Jun, I.; Han, H.-S.; Edwards, J.R.; Jeon, H. Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication. Int. J. Mol. Sci. 2018, 19, 745.

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